Search for genetic loci involved in the constitution and skin type of a Japanese women using a genome-wide association study.
Exp Dermatol
; 30(12): 1787-1793, 2021 12.
Article
in En
| MEDLINE
| ID: mdl-34265127
ABSTRACT
The constitution and skin type of individuals are influenced by various factors. Recently, the influence of genetic predispositions on these has been emphasized. To date, genome-wide association studies (GWAS) have shown several single nucleotide polymorphisms (SNPs) that affect individual's constitution and skin type. However, these studies have mainly focused on the Caucasian population, and only a few association analyses with the constitution and skin type of individuals involving a Japanese population have been conducted. In this study, we conducted a GWAS analysis of 9 phenotypes regarding the constitution or skin type of 1108 Japanese women based on a questionnaire. As a result, in addition to SNPs known to be involved in phenotypes in the past, we discovered new SNPs and genetic regions related to darkness of pigmented spots, skin flushing, frequency of rough skin and responsiveness to cosmetics.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin
/
Genetic Predisposition to Disease
Type of study:
Risk_factors_studies
Limits:
Female
/
Humans
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Exp Dermatol
Journal subject:
DERMATOLOGIA
Year:
2021
Type:
Article
Affiliation country:
Japan