Rate of RhD-alloimmunization after the transfusion of multiple RhD-positive primary red blood cell-containing products.
Transfusion
; 61 Suppl 1: S150-S158, 2021 07.
Article
in En
| MEDLINE
| ID: mdl-34269438
ABSTRACT
INTRODUCTION:
Early transfusion reduces mortality in bleeding patients. In this setting, RhD-positive blood products might be transfused. This study determined the association between the RhD-alloimmunization rate and the number of RhD-positive products transfused.METHODS:
RhD-negative patients between 13 and 50 years who were transfused with ≥1 RhD-positive red blood cell (RBC) or whole blood units between January 1, 2000 and December 31, 2019 in a healthcare network were identified. Study patients had to have had at least one antibody detection test performed ≥14 days after the index RhD-positive transfusion and not receive RhIg. Patients were stratified into groups that received 1, 2, 3-5, 6-10, 11-20, and >20 RhD-positive transfusions and the RhD-alloimmunization rate was determined for each group.RESULTS:
There were 335 patients included; 52/335 (15.5%) were females. Overall, there were 117/335 (34.9%, CI 29.8%-40.3%) recipients who became RhD-alloimmunized. There was no significant dosage effect in the RhD-alloimmunization rates as the exposure to RhD-positive units increased from one RhD-positive unit to more than 20 RhD-positive units (p = .270 for non-parametric trend test). In an exploratory analysis, patients who received 100% of their RhD-positive transfusions within 72 h of the index transfusion had a significantly higher rate of RhD-alloimmunization compared to those who were transfused over a longer period of time (42.3% vs. 21.4%, respectively; p = .001).CONCLUSION:
These results suggest that there may not be an increased RhD-alloimmunization risk with transfusing multiple RhD-positive units after one RhD-positive unit has been transfused. These findings need confirmation in larger studies.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rh-Hr Blood-Group System
/
Erythrocyte Transfusion
/
Erythrocytes
/
Isoantibodies
Type of study:
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Transfusion
Year:
2021
Type:
Article
Affiliation country:
United States