Precision Medicine and Heterogeneity of Treatment Effect in Therapies for ARDS.
Chest
; 160(5): 1729-1738, 2021 11.
Article
in En
| MEDLINE
| ID: mdl-34270967
ABSTRACT
ARDS is a clinically heterogeneous syndrome, rather than a distinct disease. This heterogeneity at least partially explains the difficulty in studying treatments for these patients and contributes to the numerous trials of therapies for the syndrome that have not shown benefit. Recent studies have identified different subphenotypes within the heterogeneous patient population. These different subphenotypes likely have variable clinical responses to specific therapies, a concept known as heterogeneity of treatment effect. Recognizing different subphenotypes and heterogeneity of treatment effect has important implications for the clinical management of patients with ARDS. This review presents studies that have identified different subphenotypes and discusses how they can modify the effects of therapies evaluated in trials that are commonly considered to have shown no overall benefit in patients with ARDS.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Respiratory Distress Syndrome
/
Genetic Heterogeneity
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
Chest
Year:
2021
Type:
Article
Affiliation country:
Canada