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Discovery of Highly Potent and Selective IRAK1 Degraders to Probe Scaffolding Functions of IRAK1 in ABC DLBCL.
Fu, Liqiang; Zhang, Jing; Shen, Bin; Kong, Linglong; Liu, Yingtao; Tu, Wangyang; Wang, Wenqian; Cai, Xin; Wang, Xiaotao; Cheng, Na; Xia, Mingxuan; Zhou, Tianyuan; Liu, Qian; Xu, Yanping; Yang, Jennifer; Gavine, Paul; Philippar, Ulrike; Attar, Ricardo; Edwards, James P; Venable, Jennifer D; Dai, Xuedong.
Affiliation
  • Fu L; Discovery Chemistry, Janssen Research & Development, Shanghai 201210, China.
  • Zhang J; Department of Biology, Janssen Research & Development, Shanghai 201210, China.
  • Shen B; Department of Biology, Janssen Research & Development, Shanghai 201210, China.
  • Kong L; Discovery Chemistry, Janssen Research & Development, Shanghai 201210, China.
  • Liu Y; Discovery Chemistry, Janssen Research & Development, Shanghai 201210, China.
  • Tu W; Discovery Chemistry, Janssen Research & Development, Shanghai 201210, China.
  • Wang W; Department of Biology, Janssen Research & Development, Shanghai 201210, China.
  • Cai X; Department of Biomarker, Janssen Research & Development, Shanghai 201210, China.
  • Wang X; Department of Biomarker, Janssen Research & Development, Shanghai 201210, China.
  • Cheng N; Department of Biology, Janssen Research & Development, Shanghai 201210, China.
  • Xia M; Department of Biology, Janssen Research & Development, Shanghai 201210, China.
  • Zhou T; Department of Biology, Janssen Research & Development, Shanghai 201210, China.
  • Liu Q; Discovery Chemistry, Janssen Research & Development, Shanghai 201210, China.
  • Xu Y; Discovery Chemistry, Janssen Research & Development, Shanghai 201210, China.
  • Yang J; Department of Biology, Janssen Research & Development, Shanghai 201210, China.
  • Gavine P; Department of Biology, Janssen Research & Development, Shanghai 201210, China.
  • Philippar U; Janssen Pharmaceutical Research & Development, Beerse 2340, Belgium.
  • Attar R; Janssen Pharmaceutical Research & Development, Spring House, Pennsylvania 19477, United States.
  • Edwards JP; Discovery Sciences, Janssen Research & Development, San Diego, California 92121, United States.
  • Venable JD; Discovery Sciences, Janssen Research & Development, San Diego, California 92121, United States.
  • Dai X; Discovery Sciences, Janssen (China) Research & Development, Shanghai 201210, P.R. China.
J Med Chem ; 64(15): 10878-10889, 2021 08 12.
Article in En | MEDLINE | ID: mdl-34279092
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphoma, Large B-Cell, Diffuse / Protein Kinase Inhibitors / Interleukin-1 Receptor-Associated Kinases / Drug Discovery / Antineoplastic Agents Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2021 Type: Article Affiliation country: China
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphoma, Large B-Cell, Diffuse / Protein Kinase Inhibitors / Interleukin-1 Receptor-Associated Kinases / Drug Discovery / Antineoplastic Agents Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2021 Type: Article Affiliation country: China