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QuantiFERON-TB Gold Plus Assay Specificity in Children and Adolescents With Suspected Tuberculosis-A Multicenter Cross-sectional Study in Spain.
Soler-Garcia, Aleix; Gamell, Anna; Santiago, Begoña; Monsonís, Manuel; Cobo-Vázquez, Elvira; Bustillo-Alonso, Matilde; Tagarro, Alfredo; Pérez-Gorricho, Beatriz; Espiau, María; Piqueras, Ana Isabel; Korta-Murua, José Javier; Rodríguez-Molino, Paula; Lobato, Zulema; Pérez-Porcuna, Tomàs; Tebruegge, Marc; Noguera-Julian, Antoni.
Affiliation
  • Soler-Garcia A; From the Infectious Diseases and Systemic Inflammatory Response in Pediatrics, Infectious Diseases Unit, Department of Pediatrics, Hospital Sant Joan de Déu Research Foundation, Barcelona, Spain.
  • Gamell A; From the Infectious Diseases and Systemic Inflammatory Response in Pediatrics, Infectious Diseases Unit, Department of Pediatrics, Hospital Sant Joan de Déu Research Foundation, Barcelona, Spain.
  • Santiago B; Pediatric Infectious Diseases Unit, Gregorio Marañón Hospital, Madrid, Spain.
  • Monsonís M; Translational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain.
  • Cobo-Vázquez E; Unidad de Enfermedades Infecciosas, Servicio de Pediatría, Hospital Universitario Miguel Servet, Zaragoza, Spain.
  • Bustillo-Alonso M; Translational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain.
  • Tagarro A; Servicio de Pediatría, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain.
  • Pérez-Gorricho B; Translational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain.
  • Espiau M; Servicio de Pediatría, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain.
  • Piqueras AI; Fundación Para la Investigación Biomédica del Hospital 12 de Octubre, Universidad Europea de Madrid, Madrid, Spain.
  • Korta-Murua JJ; Pediatric Infectious Diseases Unit, Department of Pediatrics, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
  • Rodríguez-Molino P; Pediatric Infectious Diseases and Immunodeficiencies Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Barcelona, Spain.
  • Lobato Z; Pediatric Infectious Diseases Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
  • Pérez-Porcuna T; Servicio de Pediatría, Hospital Universitario Donostia-Instituto BioDonostia, San Sebastián, Spain.
  • Tebruegge M; Departamento de Pediatría, Facultad de Medicina, EHU-UPV, San Sebastián, Spain.
  • Noguera-Julian A; Pediatric Infectious and Tropical Diseases Department, Hospital La Paz, Madrid, Spain.
Pediatr Infect Dis J ; 40(9): e348-e351, 2021 09 01.
Article in En | MEDLINE | ID: mdl-34310504
ABSTRACT
In this cross-sectional study of 284 children and adolescents with clinically or radiologically suspected tuberculosis in a low-endemic country, the QuantiFERON-TB Gold Plus assay specificity, sensitivity, positive predictive value and negative predictive value were 91.5%, 87.3%, 86.4%, and 91.2%, respectively. The specificity was higher than that observed in tuberculin skin tests performed simultaneously, but similar to previous-generation interferon-gamma release assays.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reagent Kits, Diagnostic / Tuberculosis / Interferon-gamma Release Tests Type of study: Clinical_trials / Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Country/Region as subject: Europa Language: En Journal: Pediatr Infect Dis J Journal subject: DOENCAS TRANSMISSIVEIS / PEDIATRIA Year: 2021 Type: Article Affiliation country: Spain
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reagent Kits, Diagnostic / Tuberculosis / Interferon-gamma Release Tests Type of study: Clinical_trials / Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Country/Region as subject: Europa Language: En Journal: Pediatr Infect Dis J Journal subject: DOENCAS TRANSMISSIVEIS / PEDIATRIA Year: 2021 Type: Article Affiliation country: Spain