Enantioselective Synthesis of Chiral Phosphonates via Rh/f-spiroPhos Catalyzed Asymmetric Hydrogenation of ß,ß-Disubstituted Unsaturated Phosphonates.
J Org Chem
; 86(17): 12034-12045, 2021 Sep 03.
Article
in En
| MEDLINE
| ID: mdl-34346217
The first asymmetric hydrogenation of ß,ß-diaryl unsaturated phosphonates has been realized for synthesis of ß,ß-diaryl chiral phosphonates with excellent enantioselectivities (up to 99.9% ee) catalyzed by the Rh-(R,R)-f-spiroPhos complex. Furthermore, this catalyst also exhibits comparably excellent performance for ß-aryl-ß-alkyl unsaturated phosphonates providing the corresponding chiral phosphonates with up to 99.9% ee values. This methodology provides a straightforward access to asymmetric synthesis of chiral phosphonates.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Org Chem
Year:
2021
Type:
Article
Affiliation country:
China