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Bioactive Compounds from Lemon (Citrus limon) Extract Overcome TNF-α-Induced Insulin Resistance in Cultured Adipocytes.
Sorrenti, Valeria; Consoli, Valeria; Grosso, Salvo; Raffaele, Marco; Amenta, Margherita; Ballistreri, Gabriele; Fabroni, Simona; Rapisarda, Paolo; Vanella, Luca.
Affiliation
  • Sorrenti V; Department of Drug and Health Sciences, University of Catania, 95123 Catania, Italy.
  • Consoli V; Department of Drug and Health Sciences, University of Catania, 95123 Catania, Italy.
  • Grosso S; Department of Drug and Health Sciences, University of Catania, 95123 Catania, Italy.
  • Raffaele M; Department of Drug and Health Sciences, University of Catania, 95123 Catania, Italy.
  • Amenta M; Council for Agricultural Research and Economics (CREA), Research Centre for Olive, Fruit and Citrus Crops, 95024 Acireale, Italy.
  • Ballistreri G; Council for Agricultural Research and Economics (CREA), Research Centre for Olive, Fruit and Citrus Crops, 95024 Acireale, Italy.
  • Fabroni S; Council for Agricultural Research and Economics (CREA), Research Centre for Olive, Fruit and Citrus Crops, 95024 Acireale, Italy.
  • Rapisarda P; Council for Agricultural Research and Economics (CREA), Research Centre for Olive, Fruit and Citrus Crops, 95024 Acireale, Italy.
  • Vanella L; Department of Drug and Health Sciences, University of Catania, 95123 Catania, Italy.
Molecules ; 26(15)2021 Jul 21.
Article in En | MEDLINE | ID: mdl-34361563
ABSTRACT
The consumption of plant-based food is important for health promotion, especially regarding the prevention and management of chronic diseases such as diabetes. We investigated the effects of a lemon extract (LE), containing ≥20.0% total flavanones and ≥1.0% total hydroxycinnamic acids, on insulin signaling in murine 3T3-L1 adipocytes treated with TNF-α, which was used to mimic in vitro the insulin resistance condition that characterizes diabetes mellitus. Our results showed LE increased PPARγ, GLUT4 and DGAT-1 levels, demonstrating the potential of this lemon extract in the management of insulin resistance conditions associated with TNF-α pathway activation. LE treatment further decreased the release of interleukin 6 (IL-6) and restored triglyceride synthesis, which is the main feature of a healthy adipocyte.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / Plant Extracts / Tumor Necrosis Factor-alpha / Citrus / Adipocytes / Phytochemicals Limits: Animals Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2021 Type: Article Affiliation country: Italy
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Insulin Resistance / Plant Extracts / Tumor Necrosis Factor-alpha / Citrus / Adipocytes / Phytochemicals Limits: Animals Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2021 Type: Article Affiliation country: Italy