Cascade Reaction to Selectively Synthesize Multifunctional Indole Derivatives by IrIII -Catalyzed C-H Activation.
Chemistry
; 27(52): 13123-13127, 2021 Sep 15.
Article
in En
| MEDLINE
| ID: mdl-34369008
ABSTRACT
An effective and condition-controlled way to synthesize with high selectivity a variety of functionalized indoles with potent biological properties has been developed. Notably, 2,4-dialkynyl indole products were obtained by direct double C-H bond alkynylation, whereas alkynyl at the C4 position could convert to carbonyl to generate 2-alkynyl-3,4-diacetyl indoles fast and effectively. Additionally, a one-pot relay catalytic reaction led to 2,5-di-alkynyl-3,4-diacetyl indoles when using a carbonyl group as the directing group and by controlling the type and quantity of additives. A possible mechanism was proposed based on many studies including deuterium-exchange experiments, the necessary conditions of product conversion, and the effect of water on the reaction.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Indoles
Language:
En
Journal:
Chemistry
Journal subject:
QUIMICA
Year:
2021
Type:
Article