LC-MS Identification, Isolation, and Structural Elucidation of Anti-HIV Tigliane Diterpenoids from Wikstroemia lamatsoensis.
J Nat Prod
; 84(8): 2366-2373, 2021 08 27.
Article
in En
| MEDLINE
| ID: mdl-34445872
ABSTRACT
Structurally diverse tigliane diterpenoids have drawn significant research interest for drug discovery over many decades. Using LC-MS-guided fractionation and separation, the first phytochemical investigation on Wikstroemia lamatsoensis led to the isolation of eight tiglianes (1-8), including two new compounds, wikstrocin D (1) and wikstrocin E (2). The new structures were elucidated based on extensive physicochemical and spectroscopic analyses. The characteristic ESIMS/MS fragmentations of tiglianes 1-8 were also summarized. Among the isolated tiglianes, three compounds (8, 5, and 7) showed the most potent anti-HIV activity, with IC50 values of 0.18, 3.8, and 12.8 nM, respectively.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phorbols
/
Anti-HIV Agents
/
Wikstroemia
/
Diterpenes
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
J Nat Prod
Year:
2021
Type:
Article
Affiliation country:
Japan