Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model.

Gibb, Andrew A; Murray, Emma K; Eaton, Deborah M; Huynh, Anh T; Tomar, Dhanendra; Garbincius, Joanne F; Kolmetzky, Devin W; Berretta, Remus M; Wallner, Markus; Houser, Steven R; Elrod, John W

Gibb, Andrew A; Murray, Emma K; Eaton, Deborah M; Huynh, Anh T; Tomar, Dhanendra; Garbincius, Joanne F; Kolmetzky, Devin W; Berretta, Remus M; Wallner, Markus; Houser, Steven R; Elrod, John W.

Affiliation

Gibb AA; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Murray EK; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Eaton DM; Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Huynh AT; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Tomar D; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Garbincius JF; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Kolmetzky DW; Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Berretta RM; Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Wallner M; Cardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Houser SR; Division of Cardiology, Medical University of Graz, Graz, Austria.
Elrod JW; Center for Biomarker Research in Medicine, CBmed GmbH, Graz, Austria.

JACC Basic Transl Sci ; 6(8): 650-672, 2021 Aug.

Article in En | MEDLINE | ID: mdl-34466752

Key words

BCAA, branched chain amino acids; DAG, diacylglycerol; ECM, extracellular matrix; EF, ejection fraction; ESI, electrospray ionization; ETC, electron transport chain; FC, fold change; FDR, false discovery rate; GO, gene ontology; HF, heart failure; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; LA, left atrial; LAV, left atrial volume; LV, left ventricle/ventricular; MS/MS, tandem mass spectrometry; RCR, respiratory control ratio; RI, retention index; UPLC, ultraperformance liquid chromatography; heart failure; m/z, mass to charge ratio; metabolomics; mitochondria; preserved ejection fraction; systems biology; transcriptomics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: JACC Basic Transl Sci Year: 2021 Type: Article Affiliation country: United States

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: JACC Basic Transl Sci Year: 2021 Type: Article Affiliation country: United States