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Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma.
Nguyen, Trang T T; Shang, Enyuan; Shu, Chang; Kim, Sungsoo; Mela, Angeliki; Humala, Nelson; Mahajan, Aayushi; Yang, Hee Won; Akman, Hasan Orhan; Quinzii, Catarina M; Zhang, Guoan; Westhoff, Mike-Andrew; Karpel-Massler, Georg; Bruce, Jeffrey N; Canoll, Peter; Siegelin, Markus D.
Affiliation
  • Nguyen TTT; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.
  • Shang E; Department of Biological Sciences, Bronx Community College, City University of New York, Bronx, New York, NY, USA.
  • Shu C; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.
  • Kim S; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.
  • Mela A; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.
  • Humala N; Department of Neurological Surgery, Columbia University Medical Center, New York, NY, USA.
  • Mahajan A; Department of Neurological Surgery, Columbia University Medical Center, New York, NY, USA.
  • Yang HW; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.
  • Akman HO; Department of Neurology, Columbia University Medical Center, New York, NY, USA.
  • Quinzii CM; Department of Neurology, Columbia University Medical Center, New York, NY, USA.
  • Zhang G; Proteomics and Metabolomics Core Facility, Weill Cornell Medicine, New York, NY, USA.
  • Westhoff MA; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
  • Karpel-Massler G; Department of Neurosurgery, Ulm University Medical Center, Ulm, Germany.
  • Bruce JN; Department of Neurological Surgery, Columbia University Medical Center, New York, NY, USA.
  • Canoll P; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA.
  • Siegelin MD; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA. ms4169@cumc.columbia.edu.
Nat Commun ; 12(1): 5203, 2021 09 01.
Article in En | MEDLINE | ID: mdl-34471141
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glioblastoma / Aurora Kinase A / Warburg Effect, Oncologic Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Glioblastoma / Aurora Kinase A / Warburg Effect, Oncologic Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Type: Article Affiliation country: United States