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Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells.
Donohoue, Paul D; Pacesa, Martin; Lau, Elaine; Vidal, Bastien; Irby, Matthew J; Nyer, David B; Rotstein, Tomer; Banh, Lynda; Toh, Mckenzi S; Gibson, Jason; Kohrs, Bryan; Baek, Kevin; Owen, Arthur L G; Slorach, Euan M; van Overbeek, Megan; Fuller, Christopher K; May, Andrew P; Jinek, Martin; Cameron, Peter.
Affiliation
  • Donohoue PD; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA. Electronic address: donohoue@cariboubio.com.
  • Pacesa M; Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
  • Lau E; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.
  • Vidal B; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.
  • Irby MJ; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.
  • Nyer DB; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.
  • Rotstein T; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.
  • Banh L; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.
  • Toh MS; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.
  • Gibson J; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.
  • Kohrs B; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.
  • Baek K; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.
  • Owen ALG; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.
  • Slorach EM; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.
  • van Overbeek M; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.
  • Fuller CK; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA.
  • May AP; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA. Electronic address: apmay1@gmail.com.
  • Jinek M; Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address: jinek@bioc.uzh.ch.
  • Cameron P; Caribou Biosciences, Inc., 2929 Seventh Street, Suite 105, Berkeley, CA 94710, USA. Electronic address: pscameron@gmail.com.
Mol Cell ; 81(17): 3637-3649.e5, 2021 09 02.
Article in En | MEDLINE | ID: mdl-34478654
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / CRISPR-Cas Systems / CRISPR-Associated Protein 9 Limits: Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2021 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / CRISPR-Cas Systems / CRISPR-Associated Protein 9 Limits: Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2021 Type: Article