Undifferentiated sarcoma of bone with a round to epithelioid cell phenotype harboring a novel EWSR1-SSX2 fusion identified by RNA-based next-generation sequencing.

Cordier, Fleur; Van der Meulen, Joni; Van Gaever, Bram; Lapeire, Lore; Sys, Gwen; Van Dorpe, Jo; Creytens, David

Cordier, Fleur; Van der Meulen, Joni; Van Gaever, Bram; Lapeire, Lore; Sys, Gwen; Van Dorpe, Jo; Creytens, David.

Affiliation

Cordier F; Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium.
Van der Meulen J; Molecular Diagnostics Ghent University Hospital (MDG), Ghent University Hospital, Ghent University, Ghent, Belgium.
Van Gaever B; CRIG, Cancer Research Institute Ghent, Ghent University Hospital, Ghent University, Ghent, Belgium.
Lapeire L; Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium.
Sys G; CRIG, Cancer Research Institute Ghent, Ghent University Hospital, Ghent University, Ghent, Belgium.
Van Dorpe J; Department of Medical Oncology, Ghent University Hospital, Ghent University, Ghent, Belgium.
Creytens D; CRIG, Cancer Research Institute Ghent, Ghent University Hospital, Ghent University, Ghent, Belgium.

Genes Chromosomes Cancer ; 61(1): 44-49, 2022 01.

Article in En | MEDLINE | ID: mdl-34538011

Subject(s)

Bone Neoplasms/genetics; Neoplasm Proteins/genetics; Oncogene Proteins, Fusion/genetics; RNA-Binding Protein EWS/genetics; Repressor Proteins/genetics; Sarcoma/genetics; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Bone Neoplasms/pathology; Bone Neoplasms/therapy; Epithelioid Cells/pathology; High-Throughput Nucleotide Sequencing; Humans; In Situ Hybridization, Fluorescence; Male; Middle Aged; Osteotomy; Sarcoma/pathology; Sarcoma/therapy; Sequence Analysis, RNA; Translocation, Genetic; Treatment Outcome

Key words

RNA-based next-generation sequencing; euro Ewing 2012 protocol; round cell sarcoma with EWSR1-non-ETS fusions; undifferentiated small round cell sarcomas

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Sarcoma / Bone Neoplasms / Oncogene Proteins, Fusion / RNA-Binding Protein EWS / Neoplasm Proteins Type of study: Guideline / Prognostic_studies Limits: Humans / Male / Middle aged Language: En Journal: Genes Chromosomes Cancer Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2022 Type: Article Affiliation country: Belgium

Fulltext

XML

PubMed Links

Search on Google