miR-802 Suppresses Acinar-to-Ductal Reprogramming During Early Pancreatitis and Pancreatic Carcinogenesis.

Ge, Wenjie; Goga, Algera; He, Yuliang; Silva, Pamuditha N; Hirt, Christian Kurt; Herrmanns, Karolin; Guccini, Ilaria; Godbersen, Svenja; Schwank, Gerald; Stoffel, Markus

Ge, Wenjie; Goga, Algera; He, Yuliang; Silva, Pamuditha N; Hirt, Christian Kurt; Herrmanns, Karolin; Guccini, Ilaria; Godbersen, Svenja; Schwank, Gerald; Stoffel, Markus.

Affiliation

Ge W; Institute of Molecular Health Sciences, ETH Zürich, Zürich, Switzerland.
Goga A; Institute of Molecular Health Sciences, ETH Zürich, Zürich, Switzerland.
He Y; Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, Zürich, Switzerland.
Silva PN; Institute of Molecular Health Sciences, ETH Zürich, Zürich, Switzerland.
Hirt CK; Institute of Molecular Health Sciences, ETH Zürich, Zürich, Switzerland.
Herrmanns K; Institute of Molecular Health Sciences, ETH Zürich, Zürich, Switzerland.
Guccini I; Institute of Molecular Health Sciences, ETH Zürich, Zürich, Switzerland.
Godbersen S; Institute of Molecular Health Sciences, ETH Zürich, Zürich, Switzerland.
Schwank G; Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland.
Stoffel M; Institute of Molecular Health Sciences, ETH Zürich, Zürich, Switzerland; Medical Faculty, University of Zürich, Zürich, Switzerland. Electronic address: stoffel@biol.ethz.ch.

Gastroenterology ; 162(1): 269-284, 2022 01.

Article in En | MEDLINE | ID: mdl-34547282

Subject(s)

Acinar Cells/metabolism; Carcinoma, Pancreatic Ductal/metabolism; Cell Transformation, Neoplastic/metabolism; Cellular Reprogramming; MicroRNAs/metabolism; Pancreas/metabolism; Pancreatic Neoplasms/metabolism; Pancreatitis/metabolism; Acinar Cells/pathology; Animals; Carcinoma, Pancreatic Ductal/genetics; Carcinoma, Pancreatic Ductal/pathology; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic/genetics; Cell Transformation, Neoplastic/pathology; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Mice, Transgenic; MicroRNAs/genetics; Mutation; Pancreas/pathology; Pancreatic Neoplasms/genetics; Pancreatic Neoplasms/pathology; Pancreatitis/genetics; Pancreatitis/pathology; Proto-Oncogene Proteins p21(ras)/genetics; SOX9 Transcription Factor/genetics; SOX9 Transcription Factor/metabolism; Signal Transduction

Key words

Micro-RNA; Pancreatic Cancer; Pancreatitis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pancreas / Pancreatic Neoplasms / Pancreatitis / Cell Transformation, Neoplastic / Carcinoma, Pancreatic Ductal / MicroRNAs / Cellular Reprogramming / Acinar Cells Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Gastroenterology Year: 2022 Type: Article Affiliation country: Switzerland

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