Differential DNA methylation and transcriptional signatures characterize impairment of muscle stem cells in pediatric human muscle contractures after brain injury.

Sibley, Lydia A; Broda, Nicole; Gross, Wendy R; Menezes, Austin F; Embry, Ryan B; Swaroop, Vineeta T; Chambers, Henry G; Schipma, Matthew J; Lieber, Richard L; Domenighetti, Andrea A

Sibley, Lydia A; Broda, Nicole; Gross, Wendy R; Menezes, Austin F; Embry, Ryan B; Swaroop, Vineeta T; Chambers, Henry G; Schipma, Matthew J; Lieber, Richard L; Domenighetti, Andrea A.

Affiliation

Sibley LA; Shirley Ryan AbilityLab, Chicago, Illinois, USA.
Broda N; Shirley Ryan AbilityLab, Chicago, Illinois, USA.
Gross WR; Shirley Ryan AbilityLab, Chicago, Illinois, USA.
Menezes AF; Shirley Ryan AbilityLab, Chicago, Illinois, USA.
Embry RB; NUseq Core, Northwestern University, Chicago, Illinois, USA.
Swaroop VT; Shirley Ryan AbilityLab, Chicago, Illinois, USA.
Chambers HG; Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Schipma MJ; Rady Children's Hospital and Health Center, San Diego, California, USA.
Lieber RL; Rady Children's Hospital and Health Center, San Diego, California, USA.
Domenighetti AA; Shirley Ryan AbilityLab, Chicago, Illinois, USA.

FASEB J ; 35(10): e21928, 2021 10.

Article in En | MEDLINE | ID: mdl-34559924

Subject(s)

Brain Injuries/genetics; Brain Injuries/pathology; DNA Methylation; Gene Expression Profiling; Muscle, Skeletal/pathology; Myoblasts/metabolism; Myoblasts/pathology; Transcription, Genetic; Adolescent; Azacitidine/pharmacology; Azacitidine/therapeutic use; Brain Injuries/metabolism; Cell Proliferation; Cerebral Palsy/drug therapy; Cerebral Palsy/pathology; Child; Child, Preschool; DNA Methylation/drug effects; Female; Humans; Male; Muscle, Skeletal/metabolism; Myoblasts/drug effects; Transcription, Genetic/drug effects

Key words

5-azacytidine; DNA methylation; cerebral palsy; myoblast; satellite cell

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription, Genetic / Brain Injuries / Muscle, Skeletal / DNA Methylation / Gene Expression Profiling / Myoblasts Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2021 Type: Article Affiliation country: United States

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