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Apolipoprotein E Genotype Contributes to Motor Progression in Parkinson's Disease.
Pu, Jia-Li; Jin, Chong-Yao; Wang, Zhong-Xuan; Fang, Yi; Li, Yao-Lin; Xue, Nai-Jia; Zheng, Ran; Lin, Zhi-Hao; Yan, Yi-Qun; Si, Xiao-Li; Chen, Ying; Liu, Yi; Song, Zhe; Yan, Ya-Ping; Tian, Jun; Yin, Xin-Zhen; Zhang, Bao-Rong.
Affiliation
  • Pu JL; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Jin CY; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Wang ZX; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Fang Y; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Li YL; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Xue NJ; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Zheng R; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Lin ZH; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Yan YQ; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Si XL; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Chen Y; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Liu Y; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Song Z; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Yan YP; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Tian J; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Yin XZ; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Zhang BR; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Mov Disord ; 37(1): 196-200, 2022 01.
Article in En | MEDLINE | ID: mdl-34612548
ABSTRACT

BACKGROUND:

Emerging evidence indicates that the apolipoprotein E (APOE) ε4 exacerbates α-synuclein pathology.

OBJECTIVE:

To determine whether APOE ε4 contributes to motor progression in early Parkinson's disease (PD).

METHODS:

Longitudinal data were obtained from 384 patients with PD divided into APOE ε4 carriers (n = 85) and noncarriers (n = 299) in the Parkinson's Progression Marker Initiative. Participants underwent yearly motor assessments over a mean follow-up period of 78.9 months. Repeated measures and linear mixed models were used to test the effects of APOE ε4.

RESULTS:

The motor progression was significantly more rapid in patients with PD carrying APOE ε4 than in noncarriers (ß = 0.283, P = 0.026, 95% confidence interval 0.033-0.532). Through subgroup analysis, we found that the effect of APOE ε4 was significant only in patients with high amyloid ß burden (ß = 0.761, P < 0.001, 95% confidence interval 0.0356-1.167).

CONCLUSIONS:

APOE ε4 may be associated with rapid motor progression in PD. © 2021 International Parkinson and Movement Disorder Society.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Apolipoprotein E4 Limits: Humans Language: En Journal: Mov Disord Journal subject: NEUROLOGIA Year: 2022 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Apolipoprotein E4 Limits: Humans Language: En Journal: Mov Disord Journal subject: NEUROLOGIA Year: 2022 Type: Article Affiliation country: China