First-in-class topical therapeutic omilancor ameliorates disease severity and inflammation through activation of LANCL2 pathway in psoriasis.

Tubau-Juni, Nuria; Hontecillas, Raquel; Leber, Andrew; Maturavongsadit, Panita; Chauhan, Jyoti; Bassaganya-Riera, Josep

Tubau-Juni, Nuria; Hontecillas, Raquel; Leber, Andrew; Maturavongsadit, Panita; Chauhan, Jyoti; Bassaganya-Riera, Josep.

Affiliation

Tubau-Juni N; Landos Biopharma, Inc., Blacksburg, VA, 24060, USA.
Hontecillas R; Landos Biopharma, Inc., Blacksburg, VA, 24060, USA.
Leber A; Landos Biopharma, Inc., Blacksburg, VA, 24060, USA.
Maturavongsadit P; Landos Biopharma, Inc., Blacksburg, VA, 24060, USA.
Chauhan J; Landos Biopharma, Inc., Blacksburg, VA, 24060, USA.
Bassaganya-Riera J; Landos Biopharma, Inc., Blacksburg, VA, 24060, USA. jbr@landosbiopharma.com.

Sci Rep ; 11(1): 19827, 2021 10 06.

Article in En | MEDLINE | ID: mdl-34615968

Subject(s)

Anti-Inflammatory Agents/pharmacology; Immunosuppressive Agents/pharmacology; Membrane Proteins/metabolism; Phosphate-Binding Proteins/metabolism; Psoriasis/metabolism; Signal Transduction/drug effects; Administration, Topical; Animals; Anti-Inflammatory Agents/administration & dosage; Cytokines/metabolism; Disease Models, Animal; Disease Susceptibility; Imiquimod/adverse effects; Immunosuppressive Agents/administration & dosage; Inflammation Mediators; Keratinocytes/drug effects; Keratinocytes/immunology; Keratinocytes/metabolism; Membrane Proteins/agonists; Mice; Mice, Knockout; Phosphate-Binding Proteins/agonists; Psoriasis/drug therapy; Psoriasis/etiology; Psoriasis/pathology; T-Lymphocyte Subsets/drug effects; T-Lymphocyte Subsets/immunology; T-Lymphocyte Subsets/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Psoriasis / Signal Transduction / Phosphate-Binding Proteins / Immunosuppressive Agents / Membrane Proteins / Anti-Inflammatory Agents Type of study: Etiology_studies Limits: Animals Language: En Journal: Sci Rep Year: 2021 Type: Article Affiliation country: United States

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