SARS-CoV-2 infection generates tissue-localized immunological memory in humans.
Sci Immunol
; 6(65): eabl9105, 2021 Nov 19.
Article
in En
| MEDLINE
| ID: mdl-34618554
ABSTRACT
Adaptive immune responses to SARS-CoV-2 infection have been extensively characterized in blood; however, most functions of protective immunity must be accomplished in tissues. Here, we report from examination of SARS-CoV-2 seropositive organ donors (ages 10 to 74) that CD4+ T, CD8+ T, and B cell memory generated in response to infection is present in the bone marrow, spleen, lung, and multiple lymph nodes (LNs) for up to 6 months after infection. Lungs and lung-associated LNs were the most prevalent sites for SARS-CoV-2specific memory T and B cells with significant correlations between circulating and tissue-resident memory T and B cells in all sites. We further identified SARS-CoV-2specific germinal centers in the lung-associated LNs up to 6 months after infection. SARS-CoV-2specific follicular helper T cells were also abundant in lung-associated LNs and lungs. Together, the results indicate local tissue coordination of cellular and humoral immune memory against SARS-CoV-2 for site-specific protection against future infectious challenges.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lymphocytes
/
SARS-CoV-2
/
COVID-19
/
Immunity, Cellular
/
Immunologic Memory
/
Antibodies, Viral
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Sci Immunol
Year:
2021
Type:
Article
Affiliation country:
United States