Population Pharmacokinetic Modeling and Probability of Pharmacodynamic Target Attainment for Ceftazidime-Avibactam in Pediatric Patients Aged 3 Months and Older.

Franzese, Richard C; McFadyen, Lynn; Watson, Kenny J; Riccobene, Todd; Carrothers, Timothy J; Vourvahis, Manoli; Chan, Phylinda L S; Raber, Susan; Bradley, John S; Lovern, Mark

Franzese, Richard C; McFadyen, Lynn; Watson, Kenny J; Riccobene, Todd; Carrothers, Timothy J; Vourvahis, Manoli; Chan, Phylinda L S; Raber, Susan; Bradley, John S; Lovern, Mark.

Affiliation

Franzese RC; Certara Strategic Consulting, Raleigh, North Carolina, USA.
McFadyen L; Pfizer, Sandwich, Kent, UK.
Watson KJ; Certara Strategic Consulting, Sheffield, UK.
Riccobene T; AbbVie, Madison, New Jersey, USA.
Carrothers TJ; AbbVie, Madison, New Jersey, USA.
Vourvahis M; Pfizer, New York, New York, USA.
Chan PLS; Pfizer, Sandwich, Kent, UK.
Raber S; Pfizer, La Jolla, California, USA.
Bradley JS; Rady Children's Hospital/University of California San Diego School of Medicine, San Diego, California, USA.
Lovern M; Certara Strategic Consulting, Raleigh, North Carolina, USA.

Clin Pharmacol Ther ; 111(3): 635-645, 2022 03.

Article in En | MEDLINE | ID: mdl-34687548

Subject(s)

Anti-Bacterial Agents/pharmacokinetics; Azabicyclo Compounds/pharmacokinetics; Ceftazidime/pharmacokinetics; beta-Lactamase Inhibitors/pharmacokinetics; Adolescent; Anti-Bacterial Agents/therapeutic use; Azabicyclo Compounds/therapeutic use; Ceftazidime/therapeutic use; Child; Child, Preschool; Drug Combinations; Drug Resistance, Multiple, Bacterial/drug effects; Female; Gram-Negative Bacteria/drug effects; Gram-Negative Bacterial Infections/drug therapy; Gram-Negative Bacterial Infections/microbiology; Humans; Infant; Intraabdominal Infections/drug therapy; Intraabdominal Infections/microbiology; Male; Pneumonia, Ventilator-Associated/drug therapy; Pneumonia, Ventilator-Associated/microbiology; Probability; Urinary Tract Infections/drug therapy; Urinary Tract Infections/microbiology; beta-Lactamase Inhibitors/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ceftazidime / Azabicyclo Compounds / Beta-Lactamase Inhibitors / Anti-Bacterial Agents Type of study: Risk_factors_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: Clin Pharmacol Ther Year: 2022 Type: Article Affiliation country: United States

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