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A highly-specific fully-human antibody and CAR-T cells targeting CD66e/CEACAM5 are cytotoxic for CD66e-expressing cancer cells in vitro and in vivo.
Baek, Du-San; Kim, Ye-Jin; Vergara, Sandra; Conard, Alex; Adams, Cynthia; Calero, Guillermo; Ishima, Rieko; Mellors, John W; Dimitrov, Dimiter S.
Affiliation
  • Baek DS; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address: dub5@pitt.edu.
  • Kim YJ; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Vergara S; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Conard A; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Abound Bio, Pittsburgh, PA, USA.
  • Adams C; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Calero G; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Ishima R; Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Mellors JW; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Abound Bio, Pittsburgh, PA, USA.
  • Dimitrov DS; Center for Antibody Therapeutics, Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Abound Bio, Pittsburgh, PA, USA. Electronic address: mit666666@pitt.edu.
Cancer Lett ; 525: 97-107, 2022 01 28.
Article in En | MEDLINE | ID: mdl-34740610
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Carcinoembryonic Antigen / Neuroendocrine Tumors / Prostatic Neoplasms, Castration-Resistant / Receptors, Chimeric Antigen Limits: Animals / Humans / Male Language: En Journal: Cancer Lett Year: 2022 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Carcinoembryonic Antigen / Neuroendocrine Tumors / Prostatic Neoplasms, Castration-Resistant / Receptors, Chimeric Antigen Limits: Animals / Humans / Male Language: En Journal: Cancer Lett Year: 2022 Type: Article