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Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis.
Zhang, Xinbo; McDonald, Jeffrey G; Aryal, Binod; Canfrán-Duque, Alberto; Goldberg, Emily L; Araldi, Elisa; Ding, Wen; Fan, Yuhua; Thompson, Bonne M; Singh, Abhishek K; Li, Qian; Tellides, George; Ordovás-Montanes, Jose; García Milian, Rolando; Dixit, Vishwa Deep; Ikonen, Elina; Suárez, Yajaira; Fernández-Hernando, Carlos.
Affiliation
  • Zhang X; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520.
  • McDonald JG; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520.
  • Aryal B; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390.
  • Canfrán-Duque A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520.
  • Goldberg EL; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520.
  • Araldi E; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520.
  • Ding W; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520.
  • Fan Y; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520.
  • Thompson BM; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520.
  • Singh AK; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
  • Li Q; Energy Metabolism Laboratory, Institute of Translational Medicine, Department of Health Sciences and Technology, Swiss Federal Institute of Technology Zurich, Schwerzenbach CH-8603, Switzerland.
  • Tellides G; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520.
  • Ordovás-Montanes J; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520.
  • García Milian R; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520.
  • Dixit VD; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520.
  • Ikonen E; Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390.
  • Suárez Y; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520.
  • Fernández-Hernando C; Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT 06520.
Proc Natl Acad Sci U S A ; 118(47)2021 11 23.
Article in En | MEDLINE | ID: mdl-34782454
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Desmosterol / Atherosclerosis / Inflammasomes / Inflammation / Macrophage Activation Limits: Animals / Humans / Male Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Desmosterol / Atherosclerosis / Inflammasomes / Inflammation / Macrophage Activation Limits: Animals / Humans / Male Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Type: Article