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The telomere length landscape of prostate cancer.
Livingstone, Julie; Shiah, Yu-Jia; Yamaguchi, Takafumi N; Heisler, Lawrence E; Huang, Vincent; Lesurf, Robert; Gebo, Tsumugi; Carlin, Benjamin; Eng, Stefan; Drysdale, Erik; Green, Jeffrey; van der Kwast, Theodorus; Bristow, Robert G; Fraser, Michael; Boutros, Paul C.
Affiliation
  • Livingstone J; Department of Human Genetics, University of California, Los Angeles, CA, 90095, USA.
  • Shiah YJ; Department of Urology, University of California, Los Angeles, CA, 90024, USA.
  • Yamaguchi TN; Jonsson Comprehensive Cancer Centre, University of California, Los Angeles, CA, 90024, USA.
  • Heisler LE; Institute for Precision Health, University of California, Los Angeles, CA, 90024, USA.
  • Huang V; Ontario Institute for Cancer Research, Toronto, ON, M5G 0A3, Canada.
  • Lesurf R; Department of Human Genetics, University of California, Los Angeles, CA, 90095, USA.
  • Gebo T; Department of Urology, University of California, Los Angeles, CA, 90024, USA.
  • Carlin B; Jonsson Comprehensive Cancer Centre, University of California, Los Angeles, CA, 90024, USA.
  • Eng S; Institute for Precision Health, University of California, Los Angeles, CA, 90024, USA.
  • Drysdale E; Ontario Institute for Cancer Research, Toronto, ON, M5G 0A3, Canada.
  • Green J; Ontario Institute for Cancer Research, Toronto, ON, M5G 0A3, Canada.
  • van der Kwast T; Ontario Institute for Cancer Research, Toronto, ON, M5G 0A3, Canada.
  • Bristow RG; Department of Human Genetics, University of California, Los Angeles, CA, 90095, USA.
  • Fraser M; Department of Urology, University of California, Los Angeles, CA, 90024, USA.
  • Boutros PC; Jonsson Comprehensive Cancer Centre, University of California, Los Angeles, CA, 90024, USA.
Nat Commun ; 12(1): 6893, 2021 11 25.
Article in En | MEDLINE | ID: mdl-34824250
ABSTRACT
Replicative immortality is a hallmark of cancer, and can be achieved through telomere lengthening and maintenance. Although the role of telomere length in cancer has been well studied, its association to genomic features is less well known. Here, we report the telomere lengths of 392 localized prostate cancer tumours and characterize their relationship to genomic, transcriptomic and proteomic features. Shorter tumour telomere lengths are associated with elevated genomic instability, including single-nucleotide variants, indels and structural variants. Genes involved in cell proliferation and signaling are correlated with tumour telomere length at all levels of the central dogma. Telomere length is also associated with multiple clinical features of a tumour. Longer telomere lengths in non-tumour samples are associated with a lower rate of biochemical relapse. In summary, we describe the multi-level integration of telomere length, genomics, transcriptomics and proteomics in localized prostate cancer.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Telomere Limits: Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostatic Neoplasms / Telomere Limits: Humans / Male Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2021 Type: Article Affiliation country: United States