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NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation.
Andreeva, Liudmila; David, Liron; Rawson, Shaun; Shen, Chen; Pasricha, Teerithveen; Pelegrin, Pablo; Wu, Hao.
Affiliation
  • Andreeva L; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
  • David L; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
  • Rawson S; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Harvard Cryo-EM Center for Structural Biology, Boston, MA 02115, USA.
  • Shen C; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
  • Pasricha T; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Northeastern University, Boston, MA 02115, USA.
  • Pelegrin P; Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), Universidad de Murcia, Murcia, Spain.
  • Wu H; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA. Electronic address: wu@crystal.harvard.edu.
Cell ; 184(26): 6299-6312.e22, 2021 12 22.
Article in En | MEDLINE | ID: mdl-34861190
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein Limits: Animals / Humans Language: En Journal: Cell Year: 2021 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein Limits: Animals / Humans Language: En Journal: Cell Year: 2021 Type: Article Affiliation country: United States