LncRNA CEBPA-AS1 alleviates cerebral ischemia-reperfusion injury by sponging miR-340-5p regulating APPL1/LKB1/AMPK pathway.

Tu, Xiankun; Zhang, Huabin; Chen, Song; Ding, Yi-Hang; Wu, Xiyao; Liang, Risheng; Shi, Song-Sheng

Tu, Xiankun; Zhang, Huabin; Chen, Song; Ding, Yi-Hang; Wu, Xiyao; Liang, Risheng; Shi, Song-Sheng.

Affiliation

Tu X; Department of Neurosurgery, Neurosurgical Institute of Fujian Province, Fujian Medical University Union Hospital, Fuzhou, China.
Zhang H; Department of Neurosurgery, Neurosurgical Institute of Fujian Province, Fujian Medical University Union Hospital, Fuzhou, China.
Chen S; Department of Neurosurgery, Neurosurgical Institute of Fujian Province, Fujian Medical University Union Hospital, Fuzhou, China.
Ding YH; Department of Neurosurgery, Neurosurgical Institute of Fujian Province, Fujian Medical University Union Hospital, Fuzhou, China.
Wu X; Department of Neurosurgery, Neurosurgical Institute of Fujian Province, Fujian Medical University Union Hospital, Fuzhou, China.
Liang R; Department of Neurosurgery, Neurosurgical Institute of Fujian Province, Fujian Medical University Union Hospital, Fuzhou, China.
Shi SS; Department of Neurosurgery, Neurosurgical Institute of Fujian Province, Fujian Medical University Union Hospital, Fuzhou, China.

FASEB J ; 36(1): e22075, 2022 01.

Article in En | MEDLINE | ID: mdl-34919285

Subject(s)

AMP-Activated Protein Kinase Kinases/biosynthesis; AMP-Activated Protein Kinases/biosynthesis; Adaptor Proteins, Signal Transducing/biosynthesis; Cerebrovascular Disorders/metabolism; MicroRNAs/biosynthesis; Nerve Tissue Proteins/biosynthesis; RNA, Long Noncoding/biosynthesis; Reperfusion Injury/metabolism; Signal Transduction; AMP-Activated Protein Kinase Kinases/genetics; AMP-Activated Protein Kinases/genetics; Adaptor Proteins, Signal Transducing/genetics; Animals; Apoptosis; Cerebrovascular Disorders/genetics; Cerebrovascular Disorders/pathology; Disease Models, Animal; Gene Expression Regulation; MicroRNAs/genetics; Nerve Tissue Proteins/genetics; RNA, Long Noncoding/genetics; Rats; Rats, Sprague-Dawley; Reperfusion Injury/genetics; Reperfusion Injury/pathology

Key words

APPL1/LKB1/AMPK pathway; CEBPA-AS1; MCAO/IR rat model; cerebral ischemia-reperfusion injury; miR-340-5p

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reperfusion Injury / Signal Transduction / Cerebrovascular Disorders / MicroRNAs / Adaptor Proteins, Signal Transducing / AMP-Activated Protein Kinases / RNA, Long Noncoding / AMP-Activated Protein Kinase Kinases / Nerve Tissue Proteins Type of study: Prognostic_studies Limits: Animals Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2022 Type: Article Affiliation country: China

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