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A Novel Imidazolinone Derivative with 5-Arylidene and 2-Substituted Mercapto Group as Potent Anti-Hepatitis C Virus Compound.
Kong, Ying; Mao, Chongyang; Li, Shu; Xie, Yan; Zhang, Xiao-Lian; Fu, Boqiao.
Affiliation
  • Kong Y; State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology and Department of Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan Hubei, 430071, P. R. China.
  • Mao C; Institute of Biomedical Materials Industry Technology, Hubei Co-Innovation Center for Utilization of Biomass Waste, College of Chemistry and Materials Science, Hubei Engineering University, Xiaogan Hubei, 432000, China.
  • Li S; State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology and Department of Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan Hubei, 430071, P. R. China.
  • Xie Y; State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology and Department of Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan Hubei, 430071, P. R. China.
  • Zhang XL; State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology and Department of Immunology, School of Basic Medical Sciences, Wuhan University, Wuhan Hubei, 430071, P. R. China.
  • Fu B; Institute of Biomedical Materials Industry Technology, Hubei Co-Innovation Center for Utilization of Biomass Waste, College of Chemistry and Materials Science, Hubei Engineering University, Xiaogan Hubei, 432000, China.
Chem Biodivers ; 19(2): e202100602, 2022 Feb.
Article in En | MEDLINE | ID: mdl-34927353
ABSTRACT
Here six novel imidazolinone derivatives have been synthesized and the compound 4b containing 5-para-methoxy-phenylidene and 2-thioalkylation terminal substitution with 3'-cyano-2',6'-dimethylphenyl showed the best anti-HCV activity and the lowest cytotoxicity. Selectivity index (SI=CC50 /IC50 ) for the 4b was determined as 36, indicating that compound 4b was highly selective towards HCV.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Hepacivirus Language: En Journal: Chem Biodivers Journal subject: BIOQUIMICA / QUIMICA Year: 2022 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Hepacivirus Language: En Journal: Chem Biodivers Journal subject: BIOQUIMICA / QUIMICA Year: 2022 Type: Article