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Adenovirus vectors activate Vδ2+ γδT cells in a type I interferon-, TNF-, and IL-18-dependent manner.
Provine, Nicholas M; Amini, Ali; Garner, Lucy C; FitzPatrick, Michael E B; Dold, Christina; Silva Reyes, Laura; Chinnakannan, Senthil; Oguti, Blanche; Raymond, Meriel; Troise, Fulvia; Capone, Stefania; Folgori, Antonella; Barnes, Eleanor; Rollier, Christine S; Pollard, Andrew J; Klenerman, Paul.
Affiliation
  • Provine NM; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Amini A; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Garner LC; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • FitzPatrick MEB; Translational Gastroenterology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Dold C; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Silva Reyes L; NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Chinnakannan S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Oguti B; NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Raymond M; Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK.
  • Troise F; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Capone S; NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Folgori A; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
  • Barnes E; NIHR Oxford Biomedical Research Centre, Oxford, UK.
  • Rollier CS; Nouscom, SRL, Rome, Italy.
  • Pollard AJ; Ceinge Biotechnologie Avanzate, Naples, Italy.
  • Klenerman P; ReiThera, SRL, Rome, Italy.
Eur J Immunol ; 52(5): 835-837, 2022 05.
Article in En | MEDLINE | ID: mdl-34958459
ABSTRACT
Vδ2+ γδT cells are unconventional T cells that can be activated by cytokines without TCR signaling. Adenovirus vaccine vectors activated Vδ2+ γδT cells in an interleukin 18-, TNF-, and type I interferon-dependent manner. This stimulatory capacity was associated with adenovirus vectors of non-species C origin, including the ChAdOx1 vaccine platform.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interferon Type I / T-Lymphocyte Subsets Language: En Journal: Eur J Immunol Year: 2022 Type: Article Affiliation country: United kingdom
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interferon Type I / T-Lymphocyte Subsets Language: En Journal: Eur J Immunol Year: 2022 Type: Article Affiliation country: United kingdom