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Rethinking the chemokine cascade in brain metastasis: Preventive and therapeutic implications.
Maurya, Shailendra Kumar; Khan, Parvez; Rehman, Asad Ur; Kanchan, Ranjana K; Perumal, Naveenkumar; Mahapatra, Sidharth; Chand, Hitendra S; Santamaria-Barria, Juan A; Batra, Surinder K; Nasser, Mohd Wasim.
Affiliation
  • Maurya SK; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68108, USA.
  • Khan P; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68108, USA.
  • Rehman AU; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68108, USA.
  • Kanchan RK; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68108, USA.
  • Perumal N; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68108, USA.
  • Mahapatra S; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68108, USA; Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, 68108, USA; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68108, USA.
  • Chand HS; Department of Immunology and Nanomedicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, 33199, USA.
  • Santamaria-Barria JA; Department of Surgery, University of Nebraska Medical Center, Omaha, NE, 68108, USA.
  • Batra SK; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68108, USA; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68108, USA; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Med
  • Nasser MW; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, 68108, USA; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68108, USA. Electronic address: wasim.nasser@unmc.edu.
Semin Cancer Biol ; 86(Pt 3): 914-930, 2022 11.
Article in En | MEDLINE | ID: mdl-34968667
Brain metastasis (BrM) is one of the major causes of death in cancer patients and is associated with an estimated 10-40 % of total cancer cases. The survival rate of brain metastatic patients has not improved due to intratumor heterogeneity, the survival adaptations of brain homing metastatic cells, and the lack of understanding of underlying molecular mechanisms that limit the availability of effective therapies. The heterogeneous population of immune cells and tumor-initiating cells or cancer stem cells in the tumor microenvironment (TME) release various factors, such as chemokines that upon binding to their cognate receptors enhance tumor growth at primary sites and help tumor cells metastasize to the brain. Furthermore, brain metastatic sites have unique heterogeneous microenvironment that fuels cancer cells in establishing BrM. This review explores the crosstalk of chemokines with the heterogeneous TME during the progression of BrM and recognizes potential therapeutic approaches. We also discuss and summarize different targeted, immunotherapeutic, chemotherapeutic, and combinatorial strategies (with chemo-/immune- or targeted-therapies) to attenuate chemokines mediated BrM.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms Limits: Humans Language: En Journal: Semin Cancer Biol Journal subject: NEOPLASIAS Year: 2022 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms Limits: Humans Language: En Journal: Semin Cancer Biol Journal subject: NEOPLASIAS Year: 2022 Type: Article Affiliation country: United States