Your browser doesn't support javascript.
loading
HIT 2.0: an enhanced platform for Herbal Ingredients' Targets.
Yan, Deyu; Zheng, Genhui; Wang, Caicui; Chen, Zikun; Mao, Tiantian; Gao, Jian; Yan, Yu; Chen, Xiangyi; Ji, Xuejie; Yu, Jinyu; Mo, Saifeng; Wen, Haonan; Han, Wenhao; Zhou, Mengdi; Wang, Yuan; Wang, Jun; Tang, Kailin; Cao, Zhiwei.
Affiliation
  • Yan D; Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
  • Zheng G; Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
  • Wang C; Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
  • Chen Z; Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
  • Mao T; Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
  • Gao J; International Human Phenome Institutes (Shanghai), Shanghai, China.
  • Yan Y; Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
  • Chen X; Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
  • Ji X; Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
  • Yu J; Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
  • Mo S; Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
  • Wen H; Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
  • Han W; Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
  • Zhou M; Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
  • Wang Y; Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
  • Wang J; Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
  • Tang K; Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
  • Cao Z; Dept. of Gastroenterology, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
Nucleic Acids Res ; 50(D1): D1238-D1243, 2022 01 07.
Article in En | MEDLINE | ID: mdl-34986599
ABSTRACT
Literature-described targets of herbal ingredients have been explored to facilitate the mechanistic study of herbs, as well as the new drug discovery. Though several databases provided similar information, the majority of them are limited to literatures before 2010 and need to be updated urgently. HIT 2.0 was here constructed as the latest curated dataset focusing on Herbal Ingredients' Targets covering PubMed literatures 2000-2020. Currently, HIT 2.0 hosts 10 031 compound-target activity pairs with quality indicators between 2208 targets and 1237 ingredients from more than 1250 reputable herbs. The molecular targets cover those genes/proteins being directly/indirectly activated/inhibited, protein binders, and enzymes substrates or products. Also included are those genes regulated under the treatment of individual ingredient. Crosslinks were made to databases of TTD, DrugBank, KEGG, PDB, UniProt, Pfam, NCBI, TCM-ID and others. More importantly, HIT enables automatic Target-mining and My-target curation from daily released PubMed literatures. Thus, users can retrieve and download the latest abstracts containing potential targets for interested compounds, even for those not yet covered in HIT. Further, users can log into 'My-target' system, to curate personal target-profiling on line based on retrieved abstracts. HIT can be accessible at http//hit2.badd-cao.net.
Subject(s)
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drugs, Chinese Herbal / Databases, Factual / Drug Discovery / Databases, Pharmaceutical Type of study: Diagnostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Nucleic Acids Res Year: 2022 Type: Article Affiliation country: China
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drugs, Chinese Herbal / Databases, Factual / Drug Discovery / Databases, Pharmaceutical Type of study: Diagnostic_studies / Systematic_reviews Limits: Humans Language: En Journal: Nucleic Acids Res Year: 2022 Type: Article Affiliation country: China