Cordycepin prevents and ameliorates experimental autoimmune encephalomyelitis by inhibiting leukocyte infiltration and reducing neuroinflammation.

Song, Ying-Chyi; Liu, Chuan-Teng; Lee, Hui-Ju; Yen, Hung-Rong

Song, Ying-Chyi; Liu, Chuan-Teng; Lee, Hui-Ju; Yen, Hung-Rong.

Affiliation

Song YC; Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; Chinese Medicine Research Center, China Medical University, Taichung, Taiwan; Research Center of Traditional Chinese Medicine, Department of Medical Research, China Medical University
Liu CT; Chinese Medicine Research Center, China Medical University, Taichung, Taiwan; Research Center of Traditional Chinese Medicine, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Lee HJ; Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan; Chinese Medicine Research Center, China Medical University, Taichung, Taiwan; Research Center of Traditional Chinese Medicine, Department of Medical Research, China Medical University
Yen HR; Chinese Medicine Research Center, China Medical University, Taichung, Taiwan; Research Center of Traditional Chinese Medicine, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taich

Biochem Pharmacol ; 197: 114918, 2022 03.

Article in En | MEDLINE | ID: mdl-35063441

Subject(s)

Deoxyadenosines/therapeutic use; Encephalomyelitis, Autoimmune, Experimental/prevention & control; Inflammation Mediators/antagonists & inhibitors; Leukocytes/drug effects; Animals; Cell Line, Transformed; Cells, Cultured; Deoxyadenosines/pharmacology; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental/immunology; Encephalomyelitis, Autoimmune, Experimental/metabolism; Female; Humans; Inflammation Mediators/immunology; Inflammation Mediators/metabolism; Leukocytes/immunology; Leukocytes/metabolism; Lipopolysaccharides/toxicity; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neuroinflammatory Diseases/chemically induced; Neuroinflammatory Diseases/immunology; Neuroinflammatory Diseases/metabolism; Neuroinflammatory Diseases/prevention & control; RAW 264.7 Cells; T-Lymphocytes, Cytotoxic/drug effects; T-Lymphocytes, Cytotoxic/immunology; T-Lymphocytes, Cytotoxic/metabolism; Th1 Cells/drug effects; Th1 Cells/immunology; Th1 Cells/metabolism; Th17 Cells/drug effects; Th17 Cells/immunology; Th17 Cells/metabolism

Key words

Adhesion molecules; Chemotaxis; Cordycepin; Dendritic cells; Multiple sclerosis; Neuroinflammation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Deoxyadenosines / Inflammation Mediators / Encephalomyelitis, Autoimmune, Experimental / Leukocytes Type of study: Prognostic_studies Language: En Journal: Biochem Pharmacol Year: 2022 Type: Article

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