A population of naive-like CD4+ T cells stably polarized to the TH 1 lineage.
Eur J Immunol
; 52(4): 566-581, 2022 04.
Article
in En
| MEDLINE
| ID: mdl-35092032
ABSTRACT
T-bet is the lineage-specifying transcription factor for CD4+ TH 1 cells. T-bet has also been found in other CD4+ T cell subsets, including TH 17 cells and Treg, where it modulates their functional characteristics. However, we lack information on when and where T-bet is expressed during T cell differentiation and how this impacts T cell differentiation and function. To address this, we traced the ontogeny of T-bet-expressing cells using a fluorescent fate-mapping mouse line. We demonstrate that T-bet is expressed in a subset of CD4+ T cells that have naïve cell surface markers and transcriptional profile and that this novel cell population is phenotypically and functionally distinct from previously described populations of naïve and memory CD4+ T cells. Naïve-like T-bet-experienced cells are polarized to the TH 1 lineage, predisposed to produce IFN-γ upon cell activation, and resist repolarization to other lineages in vitro and in vivo. These results demonstrate that lineage-specifying factors can polarize T cells in the absence of canonical markers of T cell activation and that this has an impact on the subsequent T-helper response.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Th1 Cells
/
T-Box Domain Proteins
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Eur J Immunol
Year:
2022
Type:
Article
Affiliation country:
United kingdom