Association of Cardiopulmonary Exercise Capacity and Adipokines in the General Population.
Int J Sports Med
; 43(7): 616-624, 2022 Jun.
Article
in En
| MEDLINE
| ID: mdl-35114706
ABSTRACT
Adipokines and cardiorespiratory fitness (CRF) are associated with the (patho)physiology of cardiometabolic diseases. Whether CRF and adipokines are related is unclear. We investigated associations of CRF with leptin, adiponectin, chemerin, resistin and vaspin. Data from the population-based Study of Health in Pomerania was used (n=1,479; median age 49 years; 51% women). Cardiopulmonary exercise testing was used to measure CRF. Circulating adipokine concentrations were measured by enzyme-linked immunosorbent assay. The association between CRF and adipokines was assessed using multivariable sex-specific quantile regression models. Higher maximum oxygen uptake was significantly associated with lower leptin (men-0.11 ng/ml; 95%-confidence interval [CI]-0.18 to-0.03 ng/ml; p<0.005; women-0.17 ng/ml; 95%-CI-0.33 to-0.02 ng/ml; p<0.05) and chemerin (men-0.26 ng/ml; 95%-CI-0.52 to-0.01 ng/ml; p<0.05; women-0.41 ng/ml; 95%-CI-0.82 to-0.01 ng/ml; p<0.05) as well as higher adiponectin concentrations (men 0.06 µg/ml; 95%-CI 0.02 to 0.11 µg/ml; p<0.05; women 0.03 µg/ml; 95%-CI-0.05 to 0.10 µg/ml; p=0.48). We found that CRF was inversely associated with leptin and chemerin in both sexes and positively associated with adiponectin only in men.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leptin
/
Adipokines
Type of study:
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Int J Sports Med
Year:
2022
Type:
Article
Affiliation country:
Germany