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Meta-analysis of epigenome-wide associations between DNA methylation at birth and childhood cognitive skills.
Caramaschi, Doretta; Neumann, Alexander; Cardenas, Andres; Tindula, Gwen; Alemany, Silvia; Zillich, Lea; Pesce, Giancarlo; Lahti, Jari M T; Havdahl, Alexandra; Mulder, Rosa; Felix, Janine F; Tiemeier, Henning; Sirignano, Lea; Frank, Josef; Witt, Stephanie H; Rietschel, Marcella; Deuschle, Michael; Huen, Karen; Eskenazi, Brenda; Send, Tabea Sarah; Ferrer, Muriel; Gilles, Maria; de Agostini, Maria; Baïz, Nour; Rifas-Shiman, Sheryl L; Kvist, Tuomas; Czamara, Darina; Tuominen, Samuli T; Relton, Caroline L; Rai, Dheeraj; London, Stephanie J; Räikkönen, Katri; Holland, Nina; Annesi-Maesano, Isabella; Streit, Fabian; Hivert, Marie-France; Oken, Emily; Sunyer, Jordi; Cecil, Charlotte A M; Sharp, Gemma.
Affiliation
  • Caramaschi D; Medical Research Council Integrative Epidemiology Unit (MRC IEU), Bristol Medical School, Population Health Science, University of Bristol, Bristol, UK. d.caramaschi@exeter.ac.uk.
  • Neumann A; Department of Psychology, College of Life and Environmental Sciences, University of Exeter, Exeter, UK. d.caramaschi@exeter.ac.uk.
  • Cardenas A; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Tindula G; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada.
  • Alemany S; Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
  • Zillich L; Children's Environmental Health Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
  • Pesce G; ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
  • Lahti JMT; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  • Havdahl A; CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain.
  • Mulder R; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
  • Felix JF; Epidemiology of Allergic and Respiratory Diseases Team (EPAR), Institute Pierre Louis of Epidemiology and Public Health, UMR-S 1136 INSERM and Sorbonne Université, Paris, France.
  • Tiemeier H; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Sirignano L; Medical Research Council Integrative Epidemiology Unit (MRC IEU), Bristol Medical School, Population Health Science, University of Bristol, Bristol, UK.
  • Frank J; Department of Mental Disorders, Norwegian Institute of Public Health and Nic Waals Institute of Lovisenberg Diaconal Hospital, Oslo, Norway.
  • Witt SH; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Rietschel M; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Deuschle M; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Huen K; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Eskenazi B; Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Send TS; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Ferrer M; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
  • Gilles M; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
  • de Agostini M; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
  • Baïz N; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
  • Rifas-Shiman SL; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Kvist T; Children's Environmental Health Laboratory, Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, USA.
  • Czamara D; Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, CA, USA.
  • Tuominen ST; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • Relton CL; ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
  • Rai D; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
  • London SJ; Inserm, Centre for Research in Epidemiology and StatisticS (CRESS), Research Team on Early Life Origins of Health (EAROH), Villejuif, France.
  • Räikkönen K; Epidemiology of Allergic and Respiratory Diseases Team (EPAR), Institute Pierre Louis of Epidemiology and Public Health, UMR-S 1136 INSERM and Sorbonne Université, Paris, France.
  • Holland N; Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
  • Annesi-Maesano I; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Streit F; Department of Translational Research in Psychiatry, Max-Planck-Institute of Psychiatry, Munich, Germany.
  • Hivert MF; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Oken E; Medical Research Council Integrative Epidemiology Unit (MRC IEU), Bristol Medical School, Population Health Science, University of Bristol, Bristol, UK.
  • Sunyer J; Medical Research Council Integrative Epidemiology Unit (MRC IEU), Bristol Medical School, Population Health Science, University of Bristol, Bristol, UK.
  • Cecil CAM; National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
  • Sharp G; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Mol Psychiatry ; 27(4): 2126-2135, 2022 04.
Article in En | MEDLINE | ID: mdl-35145228
ABSTRACT
Cognitive skills are a strong predictor of a wide range of later life outcomes. Genetic and epigenetic associations across the genome explain some of the variation in general cognitive abilities in the general population and it is plausible that epigenetic associations might arise from prenatal environmental exposures and/or genetic variation early in life. We investigated the association between cord blood DNA methylation at birth and cognitive skills assessed in children from eight pregnancy cohorts within the Pregnancy And Childhood Epigenetics (PACE) Consortium across overall (total N = 2196), verbal (total N = 2206) and non-verbal cognitive scores (total N = 3300). The associations at single CpG sites were weak for all of the cognitive domains investigated. One region near DUSP22 on chromosome 6 was associated with non-verbal cognition in a model adjusted for maternal IQ. We conclude that there is little evidence to support the idea that variation in cord blood DNA methylation at single CpG sites is associated with cognitive skills and further studies are needed to confirm the association at DUSP22.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Methylation / Epigenome Type of study: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Child / Female / Humans / Newborn / Pregnancy Language: En Journal: Mol Psychiatry Journal subject: BIOLOGIA MOLECULAR / PSIQUIATRIA Year: 2022 Type: Article Affiliation country: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Methylation / Epigenome Type of study: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Child / Female / Humans / Newborn / Pregnancy Language: En Journal: Mol Psychiatry Journal subject: BIOLOGIA MOLECULAR / PSIQUIATRIA Year: 2022 Type: Article Affiliation country: United kingdom