Bis-Iridoids from Pterocephalus hookeri and Evaluation of Their Anti-Inflammatory Activity.
Chem Biodivers
; 19(4): e202100952, 2022 Apr.
Article
in En
| MEDLINE
| ID: mdl-35166030
ABSTRACT
Four new secoiridoid-iridoid heterodimers, pterocenoids E-H (1-4), together with a known analog (5), were separated from the whole plants of Pterocephalus hookeri. Their structures were characterized by detailed spectroscopic analyses and NMR comparison with reported data for known analogs. Pterocenoid E (1) represents the first bis-iridoid example incorporating a rare trans-fused monomeric unit, and the C(8) configuration in 5 was corrected to be reversed to the original assignment. Among all the isolates, compound 5 not only showed moderate inhibition against the nitric oxide production (IC50 =36.0±4.3â
µM) but also dose-dependently suppressed the secretion of an important pro-inflammatory cytokine TNF-α, in lipopolysaccharide-induced RAW264.7 cells.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Caprifoliaceae
/
Iridoids
Limits:
Animals
Language:
En
Journal:
Chem Biodivers
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2022
Type:
Article
Affiliation country:
China