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Meropenem to Treat Valproic Acid Intoxication.
Smolders, Elise J; Ter Heine, Rob; Natsch, Stephanie; Kramers, Kees.
Affiliation
  • Smolders EJ; Department of Pharmacy, Radboud Institute of Health Sciences, Radboud University Medical Center ; and.
  • Ter Heine R; Department of Pharmacy, Radboud Institute of Health Sciences, Radboud University Medical Center ; and.
  • Natsch S; Department of Pharmacy, Radboud Institute of Health Sciences, Radboud University Medical Center ; and.
  • Kramers K; Department of Pharmacology-Toxicology and Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Ther Drug Monit ; 44(3): 359-362, 2022 06 01.
Article in En | MEDLINE | ID: mdl-35170557
ABSTRACT
ABSTRACT This therapeutic drug monitoring (TDM) grand round describes a patient with serious valproic acid intoxication. A total valproic acid level of 844 mg/L and an unbound valproic acid level of 604 mg/L were observed. Meropenem was administered to enhance the clearance of valproic acid. This off-label usage of meropenem is based on the drug-drug interaction between carbapenems and valproic acid, which reduced the level of valproic acid within 24 hours after administration.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Valproic Acid / Anticonvulsants Limits: Humans Language: En Journal: Ther Drug Monit Year: 2022 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Valproic Acid / Anticonvulsants Limits: Humans Language: En Journal: Ther Drug Monit Year: 2022 Type: Article