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Night work, chronotype and risk of endometrial cancer in the Screenwide case-control study.
Costas, Laura; Frias-Gomez, Jon; Benavente Moreno, Yolanda; Peremiquel-Trillas, Paula; Carmona, Álvaro; de Francisco, Javier; Caño, Victor; Paytubi, Sonia; Pelegrina, Beatriz; Martínez, José Manuel; Pineda, Marta; Brunet, Joan; Vidal, August; Matias-Guiu, Xavier; Bosch, Xavier; Ponce, Jordi; Kogevinas, Manolis; De Sanjosé, Silvia; Alemany, Laia.
Affiliation
  • Costas L; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain lcostas@iconcologia.net.
  • Frias-Gomez J; Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain.
  • Benavente Moreno Y; Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain.
  • Peremiquel-Trillas P; Faculty of Medicine, University of Barcelona, Barcelona, Spain.
  • Carmona Á; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
  • de Francisco J; Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain.
  • Caño V; Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain.
  • Paytubi S; Faculty of Medicine, University of Barcelona, Barcelona, Spain.
  • Pelegrina B; Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain.
  • Martínez JM; Department of Anesthesiology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Spain.
  • Pineda M; Department of Anesthesiology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Spain.
  • Brunet J; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
  • Vidal A; Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain.
  • Matias-Guiu X; Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain.
  • Bosch X; Department of Gynecology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Spain.
  • Ponce J; Hereditary Cancer Group, Catalan Institute of Oncology, IDIBELL, ONCOBELL Program, L'Hospitalet de Llobregat, Spain.
  • Kogevinas M; Consortium for Biomedical Research in Cancer (CIBERONC), Madrid, Spain.
  • De Sanjosé S; Hereditary Cancer Group, Catalan Institute of Oncology, IDIBELL, ONCOBELL Program, L'Hospitalet de Llobregat, Spain.
  • Alemany L; Consortium for Biomedical Research in Cancer (CIBERONC), Madrid, Spain.
Occup Environ Med ; 2022 Feb 24.
Article in En | MEDLINE | ID: mdl-35210289
BACKGROUND: Circadian disruption caused by night work has been associated with hormonal-related cancers such as breast and prostate cancer. Data on the role of circadian factors in the aetiology of endometrial cancer, an oestrogen-associated cancer, are scarce. METHODS: We examined the association between endometrial cancer and night shift work, chronotype (a characteristic correlating with preference for morning or evening activity) and sleep duration, in 180 incident cases and 218 hospital controls. Participants were interviewed face-to-face by trained interviewers to collect information on sociodemographic factors, familial, medical, occupational history (including work shifts), sleep duration and chronotype, and other lifestyle factors. We used logistic regression models adjusted for potential confounders to estimate ORs and 95% CIs. RESULTS: After adjustment by potential confounders, we found an inverse not statistically significant association between ever worked in night shifts and endometrial cancer (OR=0.64; 95% CI=0.35 to 1.16). Associations were irrespective of shift type (permanent or rotating nights) or duration of night work. We did not observe any statistically significant association between endometrial cancer and sleep duration, while inconsistent patterns were observed for chronotype and endometrial cancer risk. CONCLUSIONS: These data do not support a role for circadian disruption in the carcinogenesis of endometrial cancer.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Language: En Journal: Occup Environ Med Journal subject: MEDICINA OCUPACIONAL / SAUDE AMBIENTAL Year: 2022 Type: Article Affiliation country: Spain

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Etiology_studies / Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Language: En Journal: Occup Environ Med Journal subject: MEDICINA OCUPACIONAL / SAUDE AMBIENTAL Year: 2022 Type: Article Affiliation country: Spain