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Protease-anti-protease compartmentalization in SARS-CoV-2 ARDS: Therapeutic implications.
McElvaney, Oisin F; Asakura, Takanori; Meinig, Suzanne L; Torres-Castillo, Jose L; Hagan, Robert S; Gabillard-Lefort, Claudie; Murphy, Mark P; Thorne, Leigh B; Borczuk, Alain; Reeves, Emer P; Zumwalt, Ross E; Mikami, Yu; Carroll, Tomas P; Okuda, Kenichi; Hogan, Grace; McElvaney, Oliver J; Clarke, Jennifer; McEvoy, Natalie L; Mallon, Patrick W; McCarthy, Cormac; Curley, Ger; Wolfgang, Matthew C; Boucher, Richard C; McElvaney, Noel G.
Affiliation
  • McElvaney OF; Irish Centre for Genetic Lung Disease, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Dublin, Ireland; Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Asakura T; Marsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Meinig SL; Marsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Torres-Castillo JL; Division of Pulmonary Diseases and Critical Care Medicine, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Hagan RS; Marsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Division of Pulmonary Diseases and Critical Care Medicine, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Gabillard-Lefort C; Irish Centre for Genetic Lung Disease, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Dublin, Ireland; Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Murphy MP; Irish Centre for Genetic Lung Disease, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Dublin, Ireland; Royal College of Surgeons in Ireland, Dublin, Ireland. Electronic address: mmurphy@rcsi.ie.
  • Thorne LB; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Borczuk A; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Reeves EP; Irish Centre for Genetic Lung Disease, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Dublin, Ireland; Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Zumwalt RE; Department of Pathology, University of New Mexico School of Medicine, Albuquerque, NM, USA.
  • Mikami Y; Marsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Carroll TP; Irish Centre for Genetic Lung Disease, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Dublin, Ireland; Royal College of Surgeons in Ireland, Dublin, Ireland; Alpha-1 Foundation, Ireland.
  • Okuda K; Marsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Hogan G; Royal College of Surgeons in Ireland, Dublin, Ireland.
  • McElvaney OJ; Irish Centre for Genetic Lung Disease, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Dublin, Ireland; Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Clarke J; Department of Anaesthesia and Critical Care, Beaumont Hospital, Dublin, Ireland; Royal College of Surgeons in Ireland, Dublin, Ireland.
  • McEvoy NL; Department of Anaesthesia and Critical Care, Beaumont Hospital, Dublin, Ireland; Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Mallon PW; Department of Infectious Diseases, St Vincent's University Hospital, Dublin, Ireland; Centre for Experimental Pathogen Host Research (CEPHR), University College Dublin, Dublin, Ireland.
  • McCarthy C; Department of Respiratory Medicine, St Vincent's University Hospital, Dublin, Ireland; School of Medicine, University College Dublin, Dublin, Ireland.
  • Curley G; Department of Anaesthesia and Critical Care, Beaumont Hospital, Dublin, Ireland; Royal College of Surgeons in Ireland, Dublin, Ireland.
  • Wolfgang MC; Marsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Boucher RC; Marsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • McElvaney NG; Irish Centre for Genetic Lung Disease, RCSI Education and Research Centre, Beaumont Hospital, Dublin 9, Dublin, Ireland; Royal College of Surgeons in Ireland, Dublin, Ireland.
EBioMedicine ; 77: 103894, 2022 Mar.
Article in En | MEDLINE | ID: mdl-35217407
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory Distress Syndrome / Alpha 1-Antitrypsin Deficiency / COVID-19 Drug Treatment Type of study: Etiology_studies Limits: Humans Language: En Journal: EBioMedicine Year: 2022 Type: Article Affiliation country: Ireland
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory Distress Syndrome / Alpha 1-Antitrypsin Deficiency / COVID-19 Drug Treatment Type of study: Etiology_studies Limits: Humans Language: En Journal: EBioMedicine Year: 2022 Type: Article Affiliation country: Ireland