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The effect of insulin on response to intravitreal anti-VEGF injection in diabetic macular edema in type 2 diabetes mellitus.
Gurung, Rajya L; FitzGerald, Liesel M; Liu, Ebony; McComish, Bennet J; Kaidonis, Georgia; Ridge, Bronwyn; Hewitt, Alex W; Vote, Brendan Jt; Verma, Nitin; Craig, Jamie E; Burdon, Kathryn P.
Affiliation
  • Gurung RL; Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street (Private Bag 23), Hobart, Tas, 7000, Australia. rajyalaxmi.gurung@utas.edu.au.
  • FitzGerald LM; Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street (Private Bag 23), Hobart, Tas, 7000, Australia.
  • Liu E; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South, Australia.
  • McComish BJ; Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street (Private Bag 23), Hobart, Tas, 7000, Australia.
  • Kaidonis G; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South, Australia.
  • Ridge B; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South, Australia.
  • Hewitt AW; Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street (Private Bag 23), Hobart, Tas, 7000, Australia.
  • Vote BJ; School of Medicine, University of Tasmania, Hobart, TAS, Australia.
  • Verma N; School of Medicine, University of Tasmania, Hobart, TAS, Australia.
  • Craig JE; School of Medicine, University of Tasmania, Hobart, TAS, Australia.
  • Burdon KP; Department of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South, Australia.
BMC Ophthalmol ; 22(1): 94, 2022 Feb 28.
Article in En | MEDLINE | ID: mdl-35227220
ABSTRACT

OBJECTIVES:

To assess whether insulin therapy impacts the effectiveness of anti-vascular endothelial growth factor (anti-VEGF) injection for the treatment of diabetic macular edema (DME) in type 2 diabetes mellitus.

METHODS:

This was a retrospective multi-center analysis. The best-corrected visual acuity (BCVA) at 12 months, BCVA change, central macular thickness (CMT), CMT change, and cumulative injection number were compared between the insulin and the oral hypoglycemic agent (OHA) groups.

RESULTS:

The mean final BCVA and CMT improved in both the insulin (N = 137; p < 0.001; p < 0.001, respectively) and the OHA group (N = 61; p = 0.199; p < 0.001, respectively). The two treatment groups were comparable for final BCVA (p = 0.263), BCVA change (p = 0.184), final CMT (p = 0.741), CMT change (p = 0.458), and the cumulative injections received (p = 0.594). The results were comparable between the two groups when stratified by baseline vision (p > 0.05) and baseline HbA1c (p > 0.05).

CONCLUSION:

Insulin therapy does not alter treatment outcomes for anti-VEGF therapy in DME.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Macular Edema / Diabetes Mellitus, Type 2 / Diabetic Retinopathy Type of study: Etiology_studies / Observational_studies / Risk_factors_studies Limits: Humans Language: En Journal: BMC Ophthalmol Journal subject: OFTALMOLOGIA Year: 2022 Type: Article Affiliation country: Australia
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Macular Edema / Diabetes Mellitus, Type 2 / Diabetic Retinopathy Type of study: Etiology_studies / Observational_studies / Risk_factors_studies Limits: Humans Language: En Journal: BMC Ophthalmol Journal subject: OFTALMOLOGIA Year: 2022 Type: Article Affiliation country: Australia