Paeonol inhibits inflammatory response and protects chondrocytes by upregulating sirtuin 1.

Shang, Peng; Liu, Ying; Jia, Junqing

Shang, Peng; Liu, Ying; Jia, Junqing.

Affiliation

Shang P; Department of Orthopedics, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi 030032, P.R. China.
Liu Y; Department of Oncology, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.
Jia J; Department of Orthopedics, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi 030032, P.R. China.

Can J Physiol Pharmacol ; 100(4): 283-290, 2022 Apr.

Article in En | MEDLINE | ID: mdl-35235465

Subject(s)

Chondrocytes; Osteoarthritis; Acetophenones/metabolism; Acetophenones/pharmacology; Acetophenones/therapeutic use; Animals; Cells, Cultured; Chondrocytes/metabolism; Interleukin-1beta/metabolism; NF-kappa B/metabolism; Osteoarthritis/drug therapy; Osteoarthritis/pathology; Rats; Sirtuin 1/metabolism

Key words

apoptose; apoptosis; arthrose; chondrocyte; dégradation de la matrice extracellulaire; extracellular matrix degradation; inflammation; nuclear factor κß pathway; osteoarthritis; paeonol; paéonol; sirtuin 1; sirtuine 1; voie de signalisation du NF-κß

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoarthritis / Chondrocytes Limits: Animals Language: En Journal: Can J Physiol Pharmacol Year: 2022 Type: Article

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