The epitranscriptome toolbox.
Cell
; 185(5): 764-776, 2022 03 03.
Article
in En
| MEDLINE
| ID: mdl-35245480
ABSTRACT
In the last decade, the notion that mRNA modifications are involved in regulation of gene expression was demonstrated in thousands of studies. To date, new technologies and methods allow accurate identification, transcriptome-wide mapping, and functional characterization of a growing number of RNA modifications, providing important insights into the biology of these marks. Most of the methods and approaches were developed for studying m6A, the most prevalent internal mRNA modification. However, unique properties of other RNA modifications stimulated the development of additional approaches. In this technical primer, we will discuss the available tools and approaches for detecting and studying different RNA modifications.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
RNA
/
RNA Processing, Post-Transcriptional
Language:
En
Journal:
Cell
Year:
2022
Type:
Article
Affiliation country:
Israel