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Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses.
Banta, Karl L; Xu, Xiaozheng; Chitre, Avantika S; Au-Yeung, Amelia; Takahashi, Chikara; O'Gorman, William E; Wu, Thomas D; Mittman, Stephanie; Cubas, Rafael; Comps-Agrar, Laetitia; Fulzele, Amit; Bennett, Eric J; Grogan, Jane L; Hui, Enfu; Chiang, Eugene Y; Mellman, Ira.
Affiliation
  • Banta KL; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Xu X; Section of Cell & Developmental Biology, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
  • Chitre AS; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Au-Yeung A; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Takahashi C; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • O'Gorman WE; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Wu TD; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Mittman S; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Cubas R; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Comps-Agrar L; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Fulzele A; Section of Cell & Developmental Biology, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
  • Bennett EJ; Section of Cell & Developmental Biology, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
  • Grogan JL; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.
  • Hui E; Section of Cell & Developmental Biology, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
  • Chiang EY; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: chiang.eugene@gene.com.
  • Mellman I; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: mellman.ira@gene.com.
Immunity ; 55(3): 512-526.e9, 2022 03 08.
Article in En | MEDLINE | ID: mdl-35263569
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / Neoplasms Limits: Humans Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2022 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD8-Positive T-Lymphocytes / Neoplasms Limits: Humans Language: En Journal: Immunity Journal subject: ALERGIA E IMUNOLOGIA Year: 2022 Type: Article Affiliation country: United States