Frailty as a predictor of mortality in COVID-19 patients receiving CPAP for respiratory insufficiency.
Aging Clin Exp Res
; 34(4): 945-949, 2022 Apr.
Article
in En
| MEDLINE
| ID: mdl-35298829
ABSTRACT
OBJECTIVE:
Exploring the association between frailty and mortality in a cohort of patients with COVID-19 respiratory insufficiency treated with continuous positive airway pressure.METHODS:
Frailty was measured using a Frailty Index (FI) created by using the baseline assessment data on comorbidities and body mass index and baseline blood test results (including pH, lactate dehydrogenase, renal and liver function, inflammatory indexes and anemia). FI > 0.25 identified frail individuals.RESULTS:
Among the 159 included individuals (81% men, median age of 68) frailty was detected in 69% of the patients (median FI score 0.3 ± 0.08). Frailty was associated to an increased mortality (adjusted HR 1.99, 95% CI 1.02-3.88, p = 0.04).CONCLUSIONS:
Frailty is highly prevalent among patients with COVID-19, predicts poorer outcomes independently of age. A personalization of care balancing the risk and benefit of treatments (especially the invasive ones) in such complex patients is pivotal.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Respiratory Insufficiency
/
Frailty
/
COVID-19
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
En
Journal:
Aging Clin Exp Res
Journal subject:
GERIATRIA
Year:
2022
Type:
Article
Affiliation country:
Italy