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Platinum-based chemotherapy inflames the ovarian carcinoma microenvironment through cellular senescence.
Álvarez-Abril, Beatriz; García-Martínez, Elena; Galluzzi, Lorenzo.
Affiliation
  • Álvarez-Abril B; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
  • García-Martínez E; Department of Hematology and Oncology, Morales Meseguer University Hospital, Murcia, Spain.
  • Galluzzi L; Department of Hematology and Oncology, Morales Meseguer University Hospital, Murcia, Spain.
Oncoimmunology ; 11(1): 2052411, 2022.
Article in En | MEDLINE | ID: mdl-35309729
ABSTRACT
Epithelial ovarian carcinoma (EOC) is virtually insensitive to immune checkpoint inhibitors (ICIs). Recent findings from an innovative mouse model of EOC demonstrate that senescence induction underlies the increased sensitivity of homologous recombination-defective EOCs to platinum-based chemotherapy as it initiates tumor infiltration by immune effector cells coupled to restored sensitivity to ICIs.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms Type of study: Prognostic_studies Limits: Animals Language: En Journal: Oncoimmunology Year: 2022 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms Type of study: Prognostic_studies Limits: Animals Language: En Journal: Oncoimmunology Year: 2022 Type: Article Affiliation country: United States