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Impact of Drug Conjugation on Thermal and Metabolic Stabilities of Aglycosylated and N-Glycosylated Antibodies.
Yamazoe, Sayumi; Kotapati, Srikanth; Hogan, Jason M; West, Sean M; Deng, Xiaodi A; Diong, S J; Arbanas, Jaren; Nguyen, Thien Anh; Jashnani, Aarti; Gupta, Diksha; Rajpal, Arvind; Dollinger, Gavin; Strop, Pavel.
Affiliation
  • Yamazoe S; Discovery Biotherapeutics, Bristol-Myers Squibb, 700 Bay Road, Redwood City, California 94063, United States.
  • Kotapati S; Discovery Biotherapeutics, Bristol-Myers Squibb, 700 Bay Road, Redwood City, California 94063, United States.
  • Hogan JM; Discovery Biotherapeutics, Bristol-Myers Squibb, 700 Bay Road, Redwood City, California 94063, United States.
  • West SM; Discovery Biotherapeutics, Bristol-Myers Squibb, 700 Bay Road, Redwood City, California 94063, United States.
  • Deng XA; Dren Bio, 400 Seaport Ct, Ste 102, Redwood City, California 94063, United States.
  • Diong SJ; Discovery Biotherapeutics, Bristol-Myers Squibb, 700 Bay Road, Redwood City, California 94063, United States.
  • Arbanas J; Discovery Biotherapeutics, Bristol-Myers Squibb, Princeton, New Jersey 08543, United States.
  • Nguyen TA; Discovery Biotherapeutics, Bristol-Myers Squibb, 700 Bay Road, Redwood City, California 94063, United States.
  • Jashnani A; Discovery Biotherapeutics, Bristol-Myers Squibb, 700 Bay Road, Redwood City, California 94063, United States.
  • Gupta D; SCIEX, 47370 Fremont Blvd, Fremont, California 94538, United States.
  • Rajpal A; Large Molecule Drug Discovery, Genentech, 1 DNA Way, South San Francisco, California 94080, United States.
  • Dollinger G; Discovery Biotherapeutics, Bristol-Myers Squibb, 700 Bay Road, Redwood City, California 94063, United States.
  • Strop P; Discovery Biotherapeutics, Bristol-Myers Squibb, 700 Bay Road, Redwood City, California 94063, United States.
Bioconjug Chem ; 33(4): 576-585, 2022 04 20.
Article in En | MEDLINE | ID: mdl-35344340
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Immunoconjugates Language: En Journal: Bioconjug Chem Journal subject: BIOQUIMICA Year: 2022 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Immunoconjugates Language: En Journal: Bioconjug Chem Journal subject: BIOQUIMICA Year: 2022 Type: Article Affiliation country: United States