Mitochondrien als universelle Sensoren der akuten Hypoxie?
Biospektrum (Heidelb)
; 28(2): 132-134, 2022.
Article
in De
| MEDLINE
| ID: mdl-35369109
ABSTRACT
Adaptation to acute hypoxia through cardiorespiratory responses is mediated by specialized cells in the carotid body and pulmonary vasculature to optimize systemic arterial oxygenation. Acute oxygen sensing thus is a fundamental pre-requisite for aerobic life. Recent studies unravelled basic oxygen sensing mechanisms involving the mitochondrial cytochrome c oxidase subunit 4 isoform 2 that regulates the release of mitochondrial reactive oxygen species and subsequent acute hypoxic responses.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
De
Journal:
Biospektrum (Heidelb)
Year:
2022
Type:
Article