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CoH-catalyzed radical hydroalkylation of alkenes with 1,3-dicarbonyls.
Guan, Meihui; Miao, Huanran; Qin, Tao; Zhang, Ge; Zhang, Qian.
Affiliation
  • Guan M; Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry, Northeast Normal University, Changchun 130024, China. zhangg492@nenu.edu.cn.
  • Miao H; Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry, Northeast Normal University, Changchun 130024, China. zhangg492@nenu.edu.cn.
  • Qin T; Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry, Northeast Normal University, Changchun 130024, China. zhangg492@nenu.edu.cn.
  • Zhang G; Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry, Northeast Normal University, Changchun 130024, China. zhangg492@nenu.edu.cn.
  • Zhang Q; Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Department of Chemistry, Northeast Normal University, Changchun 130024, China. zhangg492@nenu.edu.cn.
Chem Commun (Camb) ; 58(34): 5265-5268, 2022 Apr 26.
Article in En | MEDLINE | ID: mdl-35389410
ABSTRACT
Metal-hydride hydrogen atom transfer (MHAT) catalysis has emerged as a useful reaction platform for alkene hydrofunctionalization with high chemoselectivity and predictable branched selectivity. However, MHAT-mediated hydrofunctionalization involves carbon-carbon bond formation still confined to carbon electrophiles. Here, we describe a mild, general, scalable, and functional group tolerant CoH-catalyzed intermolecular hydroalkylation of alkenes with 1,3-dicarbonyls. This kind of CoH-catalyzed coupling of alkenes with carbon nucleophiles represents an important complement to the arsenal of MHAT-initiated hydrofunctionalization of alkenes.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alkenes / Hydrogen Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2022 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alkenes / Hydrogen Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2022 Type: Article Affiliation country: China