The CSF in neurosarcoidosis contains consistent clonal expansion of CD8 T cells, but not CD4 T cells.
J Neuroimmunol
; 367: 577860, 2022 06 15.
Article
in En
| MEDLINE
| ID: mdl-35405431
ABSTRACT
The tissue-specific drivers of neurosarcoidosis remain poorly defined. To identify cerebrospinal fluid (CSF) specific, antigen-driven T and B cell responses, we performed single-cell RNA sequencing of CSF and blood cells from neurosarcoid participants coupled to T and B cell receptor sequencing. In contrast to pulmonary sarcoidosis, which is driven by CD4 T cells, we found CD8 T cell clonal expansion enriched in the neurosarcoid CSF. These CSF-enriched CD8 T cells were composed of two subsets with differential expression of EBI2, CXCR3, and CXCR4. Lastly, our data suggest that IFNγ signaling may distinguish neurosarcoidosis from other neurological disorders.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sarcoidosis
/
Central Nervous System Diseases
Limits:
Humans
Language:
En
Journal:
J Neuroimmunol
Year:
2022
Type:
Article