The Role of Kynurenines Produced by Indolamine-2,3-Dioxygenase 1 in Sepsis.

Lerch, Simon; Schefold, Joerg C; Spinetti, Thibaud

Lerch, Simon; Schefold, Joerg C; Spinetti, Thibaud.

Affiliation

Lerch S; Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Schefold JC; Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, joerg.schefold@insel.ch.
Spinetti T; Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Pharmacology ; 107(7-8): 359-367, 2022.

Article in En | MEDLINE | ID: mdl-35413710

Subject(s)

Kynurenine; Sepsis; Animals; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase/metabolism; Kynurenine/metabolism; Mice; Sepsis/drug therapy; Sepsis/metabolism; T-Lymphocytes, Regulatory/metabolism; Tryptophan/metabolism

Key words

Indolamine-2,3-dioxygenase 1; Indolamine-2,3-dioxygenase 1 activation; Kynurenine; Kynurenine pathway; Sepsis; Sepsis-associated immunosuppression; Tryptophan

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sepsis / Kynurenine Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Pharmacology Year: 2022 Type: Article Affiliation country: Switzerland

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