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The impact of reproductive factors on DNA methylation-based telomere length in healthy breast tissue.
Sehl, Mary E; Henry, Jill E; Storniolo, Anna Maria; Horvath, Steve; Ganz, Patricia A.
Affiliation
  • Sehl ME; Medicine, Hematology-Oncology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA. msehl@mednet.ucla.edu.
  • Henry JE; Computational Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA. msehl@mednet.ucla.edu.
  • Storniolo AM; UCLA-Jonsson Comprehensive Cancer Center, Los Angeles, USA. msehl@mednet.ucla.edu.
  • Horvath S; Susan G. Komen Tissue Bank at the Indiana University Simon Cancer Center, Indianapolis, IN, 46202, USA.
  • Ganz PA; Susan G. Komen Tissue Bank at the Indiana University Simon Cancer Center, Indianapolis, IN, 46202, USA.
NPJ Breast Cancer ; 8(1): 48, 2022 Apr 13.
Article in En | MEDLINE | ID: mdl-35418123
Estrogen promotes breast tissue proliferation and telomerase activation. We investigated the effects of reproductive history on cell cycling and telomere length using a DNA methylation-based estimate of telomere length (DNAmTL) in breast and blood from healthy women donors. We demonstrate that DNAmTL is shorter in breast than in blood, and that nulliparous women have longer age-adjusted DNAmTL in both breast and blood, potentially explaining their higher risk of breast cancer.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: NPJ Breast Cancer Year: 2022 Type: Article Affiliation country: United States
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: NPJ Breast Cancer Year: 2022 Type: Article Affiliation country: United States