Your browser doesn't support javascript.
loading
A Clinical Practice Guideline for the Emergency Management of Anaphylaxis (2020).
Li, Xiaotong; Ma, Qingbian; Yin, Jia; Zheng, Ya'an; Chen, Rongchang; Chen, Yuguo; Li, Tianzuo; Wang, Yuqin; Yang, Kehu; Zhang, Hongjun; Tang, Yida; Chen, Yaolong; Dong, Hailong; Gu, Qinglong; Guo, Daihong; Hu, Xuehui; Xie, Lixin; Li, Baohua; Li, Yuzhen; Lin, Tongyu; Liu, Fang; Liu, Zhiqiang; Lyu, Lanting; Mei, Quanxi; Shao, Jie; Xin, Huawen; Yang, Fan; Yang, Hui; Yang, Wanhua; Yao, Xu; Yu, Chunshui; Zhan, Siyan; Zhang, Guoqiang; Wang, Minggui; Zhu, Zhu; Zhou, Baoguo; Gu, Jianqing; Xian, Mo; Lyu, Yuan; Li, Zhengqian; Zheng, Hangci; Cui, Chang; Deng, Shuhua; Huang, Chao; Li, Lisha; Liu, Pengfei; Men, Peng; Shao, Chunli; Wang, Sai; Ma, Xiang.
Affiliation
  • Li X; Department of Pharmacy, Peking University Third Hospital, Beijing, China.
  • Ma Q; School of Pharmaceutical Science, Peking University, Beijing, China.
  • Yin J; Institute for Drug Evaluation, Peking University Health Science Center, Beijing, China.
  • Zheng Y; Emergency Department, Peking University Third Hospital, Beijing, China.
  • Chen R; Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Chen Y; Emergency Department, Peking University Third Hospital, Beijing, China.
  • Li T; State Key Laboratory for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Wang Y; Department of Emergency Medicine and Chest Pain Center, Qilu Hospital of Shandong University, Institute of Emergency and Critical Care Medicine of Shandong University, Ji'nan, China.
  • Yang K; Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
  • Zhang H; Pharmacy Department, Xuanwu Hospital of Capital Medical University, Beijing, China.
  • Tang Y; Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
  • Chen Y; Departments of Nursing, Peking University Third Hospital, Beijing, China.
  • Dong H; Department of Internal Medicine, Coronary Heart Disease Center, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Gu Q; Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China.
  • Guo D; Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
  • Hu X; Department of Otolaryngology, Children's Hospital Affiliated to Capital Institute of Pediatrics, Beijing, China.
  • Xie L; Pharmacy Department, Chinese PL A General Hospital, Beijing, China.
  • Li B; Department of Nursing, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
  • Li Y; Department of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China.
  • Lin T; Departments of Nursing, Peking University Third Hospital, Beijing, China.
  • Liu F; Department of Pharmacy, Peking University People's Hospital, Beijing, China.
  • Liu Z; State Key Laboratory of Oncology in South China, Department of Medical Oncology, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
  • Lyu L; Department of Pharmacy, Peking University Third Hospital, Beijing, China.
  • Mei Q; Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.
  • Shao J; School of Public Administration and Policy, Renmin University of China, Beijing, China.
  • Xin H; Health Technology Assessment and Health Policy Research Group at Renmin University of China, Beijing, China.
  • Yang F; Department of Pharmacy, Shenzhen Bao'an Pure Chinese Medicine Treatment Hospital, Shenzhen, China.
  • Yang H; Department of Pediatrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Yang W; Department of Clinical Pharmacology, General Hospital of Central Theater Command of PLA, Wuhan, China.
  • Yao X; Institute of Antibiotics, Huashan Hospital Fudan University, Shanghai, China.
  • Yu C; Departments of Nursing, The First Hospital of Shanxi Medical University, Taiyuan, China.
  • Zhan S; Department of Pharmacy, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Zhang G; Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.
  • Wang M; Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China.
  • Zhu Z; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.
  • Zhou B; Department of Emergency, China-Japan Friendship Hospital, Beijing, China.
  • Gu J; Institute of Antibiotics, Huashan Hospital Fudan University, Shanghai, China.
  • Xian M; Department of Pharmacy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
  • Lyu Y; Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
  • Li Z; Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Zheng H; State Key Laboratory for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Cui C; Department of Emergency Medicine and Chest Pain Center, Qilu Hospital of Shandong University, Institute of Emergency and Critical Care Medicine of Shandong University, Ji'nan, China.
  • Deng S; Department of Anesthesiology, Peking University Third Hospital, Beijing, China.
  • Huang C; Department of Pharmacy, Peking University Third Hospital, Beijing, China.
  • Li L; School of Pharmaceutical Science, Peking University, Beijing, China.
  • Liu P; Department of Pharmacy, Peking University Third Hospital, Beijing, China.
  • Men P; School of Pharmaceutical Science, Peking University, Beijing, China.
  • Shao C; Departments of Nursing, Peking University Third Hospital, Beijing, China.
  • Wang S; National Center for Medical Service Administration, National Health Commission of the People's Republic of China, Beijing, China.
  • Ma X; Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Front Pharmacol ; 13: 845689, 2022.
Article in En | MEDLINE | ID: mdl-35418863
Background: For anaphylaxis, a life-threatening allergic reaction, the incidence rate was presented to have increased from the beginning of the 21st century. Underdiagnosis and undertreatment of anaphylaxis are public health concerns. Objective: This guideline aimed to provide high-quality and evidence-based recommendations for the emergency management of anaphylaxis. Method: The panel of health professionals from fifteen medical areas selected twenty-five clinical questions and formulated the recommendations with the supervision of four methodologists. We collected evidence by conducting systematic literature retrieval and using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach. Results: This guideline made twenty-five recommendations that covered the diagnosis, preparation, emergency treatment, and post-emergency management of anaphylaxis. We recommended the use of a set of adapted diagnostic criteria from the American National Institute of Allergy and Infectious Diseases and the Food Allergy and Anaphylaxis Network (NIAID/FAAN), and developed a severity grading system that classified anaphylaxis into four grades. We recommended epinephrine as the first-line treatment, with specific doses and routes of administration for different severity of anaphylaxis or different conditions. Proper dosage is critical in the administration of epinephrine, and the monitor is important in the IV administration. Though there was only very low or low-quality evidence supported the use of glucocorticoids and H1 antagonists, we still weakly recommended them as second-line medications. We could not make a well-directed recommendation regarding premedication for preventing anaphylaxis since it is difficult to weigh the concerns and potential effects. Conclusion: For the emergency management of anaphylaxis we conclude that: • NIAID/FAAN diagnostic criteria and the four-tier grading system should be used for the diagnosis • Prompt and proper administration of epinephrine is critical.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Guideline Language: En Journal: Front Pharmacol Year: 2022 Type: Article Affiliation country: China

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Guideline Language: En Journal: Front Pharmacol Year: 2022 Type: Article Affiliation country: China