Synthesis of acyloin natural products by Mukaiyama hydration.
Org Biomol Chem
; 20(19): 4038-4047, 2022 05 18.
Article
in En
| MEDLINE
| ID: mdl-35506986
ABSTRACT
The acyloin natural products are a family of bioactive compounds isolated from fungi and myxobacteria. The total synthesis of 7 members of the acyloin family was achieved via a HWE reaction followed by Mukaiyama-Isayama hydration, using novel Co(II) and Co(III) Schiff base SALPN complexes as catalysts for the key enone hydration step. Furthermore, we have shown that a mild acyloin rearrangement is possible under Mukaiyama hydration conditions, which was crucial in the success of this approach.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biological Products
Language:
En
Journal:
Org Biomol Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2022
Type:
Article
Affiliation country:
Australia